血清性激素与原发性高血压病的关系探讨  

Study on the Relationship Between Serum Sex Hormones Levels and Essential Hypertension

作　　者：宋庆璋[1] 杨秀红[1] 狄芳[2] 

机构地区：[1]山东省莱芜市人民医院检验科,271100 [2]莱芜市莱城区疾病预防控制中心检验科,271100

出　　处：《放射免疫学杂志》2006年第2期109-110,共2页Journal of Radioimmanology

摘　　要：目的:探讨原发性高血压(EH)发病与性激素之间可能存在的关系。方法:用放射免疫分析了87例男性EH患者及81例女性绝经后EH患者和相应正常对照组的血清性激素(LH、FSH、E2、P、T)水平,并进行高血压分期对照分析。结果:男、女EH患者血清E2、P、T水平均显著高于对照组(P<0.01);血清LH、FSH水平均低于对照组,其中男性EH组FSH水平和对照组相比下降不明显(P>0.05)。Ⅰ、Ⅱ、Ⅲ期EH患者性激素水平经F检验无显著差异(P>0.05)。相关分析显示,男性EH组E2水平和女性EH组P水平与FSH、LH水平变化无明显相关关系(P>0.05)。结论:EH患者血清E2、P、T水平显著高于对照组,且E2、P与FSH、LH之间又无相关关系,Ⅰ、Ⅱ、Ⅲ期之间性激素水平又无显著差异。血清性激素水平的变化可能是一个高血压独立的危险因子,可作为EH病部分病因的推测和提示。Objective To investigate the possible relationship existing between serum sex hormones levels development of essential hypertension. Methods Serum sex hormones （LH, FSH, E2, P, T） levels were determined with RIA in 87 males and 81 post - menopausal women with essential hypentension as well as in 44 normotensive males and 40 normotenisve post - menopausal women serving as controls. Results The serum E2, progestrone and testosterone levels in the hypertensives were significandy higher than those in the respective controls （P 〈 0. 01 ）, while serum LH and FSH levels were significandy lower with the exception of serum FSH in male hypertensives （vs controls, P 〉 0.05）. Sex hormones levels were not much different among hypertensives of various stages （ Ⅰ、Ⅱ、Ⅲ ）. The serum E2 levels in male hypertensives and progesterone levels in female hypertensives were not correlated with the respective FSH and LH levels. Gonclusion The authors suggested that the changes of serum sex hormones levels might be a risk factor rather than a consequence of the development of essential hypertension.

关 键 词：高血压 原发性 性激素 放射免疫分析 

分 类 号：R544.1[医药卫生—心血管疾病] R711.75[医药卫生—内科学]