ACS患者血浆ADM、ET-1、GMP-140水平变化及临床意义  被引量:1

Clinical Significance of Changes of Plasma ADM, ET-1 and GMP-140 Levels in Patients with Acute Coronary Syndrome (ACS)

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作  者:蔡庆岭[1] 张霞[1] 梁凤泉[1] 荆会娟[1] 

机构地区:[1]山东省聊城市第二人民医院,252601

出  处:《放射免疫学杂志》2006年第2期110-112,共3页Journal of Radioimmanology

摘  要:目的:研究急性冠脉综合征(ACS)患者血浆肾上腺髓质素(ADM)、内皮素(ET-1)和GMP-140的水平变化,探讨它们在急性冠脉综合征发生发展中的意义。方法:随机选择63例急性冠脉综合征患者作为研究组,并分为两个亚组:不稳定心绞痛(UAP)和无ST段抬高的心肌梗死(NSTEMI)31例为UAP/NSTEMI组;ST段抬高的急性心肌梗死(STEMI)32例为STEMI组。并随机选择稳定型心绞痛(SAP)患者31例为SAP组。33例正常人作为对照组。用放射免疫分析测定ADM、ET-1和GMP-140含量。结果:①血浆ADM、ET-1和GMP-140含量UAP/NSTEMI组、STEMI组均高于对照组(P<0.01)。②对照组与SPA组含量差异无统计学意义(P>0.05)。③SAP组、UAP/NSTEMI组、STEMI组之间含量有显著性差异(P<0.01)。④血浆ADM、ET-1、GMP-140之间呈正相关。结论:①血浆ADM、ET-1和GMP-140之间的相互调节、相互作用在急性冠脉综合征的发生发展中起重要作用。②血浆ADM、ET-1和GMP-140可以反映急性冠脉综合征的严重程度,可作为检测急性冠脉综合征不稳定斑块的生化指标。Objective To investigate the clinical significance of changes of plasma levels of adrenomedullin (ADM), ET - 1 and α - granule membrane protein ( GMP - 140) levels in the pathogenesis of acute coronary syndrome (ACS). Methods Plasma ADM, ET - 1 and GMP - 140 levels were measured with RIA in ① 31 cases of ACS with unstable angina pectoris (UAP) or non - ST segment elevation myocardial infarction (NSTEMI), ②32 cases of ACS with ST segment elevation myocardial infarction (STEMI), ③ 31 patients with stable angina pectoris (SAP) and,④ 33 controls. Results The plasma ADM, ET - 1 and GMP - 140 levels in both patient groups with USP/NSTEMI and STEMI were significantly higher than those in controls (P 〈0. 01 ). The plasma levels of these substances were not much different between patients with SAP and controls (P 〉 0.05). However, the plasma levels of ADM, ET - 1 and GMP - 140 in the three groups of patients ( 2 groups of ACS and 1 group of SAP) were significantly different from each other ( P 〈 0.01 ). Plasma levels of ADM, ET - 1 and GMP - 140 were matually positively correlated. Conclusion Changes of plasma levels of ADM, ET - 1 and GMP - 140 might reflect the severity of acute coronary syndrome and might serve as a marker for instability of the atheromatous plaques.

关 键 词:急性冠脉综合征 肾上腺髓质素 内皮素 Α-颗粒膜蛋白 

分 类 号:R541.4[医药卫生—心血管疾病] R541.6[医药卫生—内科学]

 

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