Graves病的遗传学研究  

Genetics research of Graves disease.

作　　者：李玟[1] 刘鸿禧[1] 林珏龙[1] 

机构地区：[1]汕头大学医学院,汕头515031

出　　处：《中国优生与遗传杂志》2006年第5期9-11,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨G raves病的遗传基础。方法采用SCE观察、G raves病遗传率分析和外周血自发微核率测定等。结果甲亢组与对照组无论是平均自发的SCE频率还是用MMC诱发的SCE频率,两者均有极显著性差异(P<0.01)。另外,两组MMC诱发的SCE频率增加数,也有显著性差异(P<0.01);甲亢组一级亲属的患病率为对照组的22.3倍。经χ2检验甲亢具有明显的家族倾向。此外,本地区甲亢h2为68.6±3.8%;20例甲亢组和对照组平均微核率分别为2.55±0.36和0.95±0.76,经χ2检验,两者有显著性差异(P<0.01)。Objective ： To study genetic bases of graves disease. Methods ： Use to observation of sister chromatid exchange; heritability rate analysis and the spontaneous micronucleus rate detection of the lymphocyte cell in Graves patient＇s peripheral blood. Results： Only mean spontaneous SCE frequency but MMC induced SCE frequency, there are very significantly difference （ P 〈 0. 01 ） in the hyperthroidiom group and control group. Other, there are significantly difference （ P 〈0. 01 ） of the increment of the MMC induced SCE frequency in above two groups ; Morbihty rate of the first relatives of patient group is 22. 3 time than the control groqp, by x^2 test, P 〈0. 01; there are 34 cases to have obvious family history in the 204 cases of proband of graves disease, to take 16. 7% in the proband total, expressing hyperthyroidism to posses tendency of family history; the heritabihty of graves is 68. 6 ± 3.8% in the shantou region; the micronucleus rate of 20 cases patients group and 20 cases control group is respectively 2. 55 ± 0. 36 and 0. 95 ± 0. 76, there are significantly difference （ P 〈0. 01 ） .

关 键 词：GRAVES病 SCE 遗传率 微核 

分 类 号：R581.1[医药卫生—内分泌]