SHBG等指标在单纯饮食控制的妊娠期糖尿病患者血清中的变化研究  

Changes and significance of sex hormone binding glubulin levels in maternal serum with gestational diabetes mellitus by simply diet control.

作　　者：高红[1] 裴丽鹏[2] 金镇[3] 卢潭敏[2] 

机构地区：[1]中国人民解放军第202医院,沈阳110003 [2]大连医科大学,大连116027 [3]中国医科大学第二临床医院,沈阳110003

出　　处：《中国优生与遗传杂志》2006年第5期34-35,42,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的检测单纯饮食控制治疗的妊娠期糖尿病(GDM)患者血清中性激素结合球蛋白(SHBG)、空腹胰岛素(FINS)、空腹血糖(FBG)水平和胰岛素抵抗(IR),探讨SHBG等指标在单纯饮食控制的GDM患者血清中的变化。方法用酶连免疫吸附法(ELISA)测定26例妊娠期糖尿病患者单纯饮食控制前后的静脉血血清中SHBG和FINS、FBG水平和IR。结果治疗后血糖浓度明显降低,P<0.05;单纯饮食控制后的GDM血清中SHBG的浓度明显高于治疗前,P<0.05;而FINS、IR则无明显变化。结论单纯的饮食控制一周就能使FBG、SHBG的指标发生变化。饮食控制确是GDM首选并有效的治疗方法,同时SHBG可作为早期预测GDM治疗疗效的一个敏感指标。Objective： To investigate the level of sex hormone binding globulin, FBG, Fins and IR in maternal serum with gestational diabetes mellitus by simply diet control, in order to find their changes in serum. Methods： Enzyme linked immunosorbent assay （ELISA） was used to determine serum SHBG FBG, Fins and IR levels in 26 maternal serum with gestational diabetes mellitus before and after simply diet control. Results： The blood glucose level were significantly lower than that in without diet control （ P 〈 0. 05 ）, and the SHBG were significantly higher （ P 〈 0. 05 ） . FINS, FBG, IR in two groups were no remarkable difference. Conclusion： FBG and SHBG levels were significantly change by only one week die control. So diet control is first thinkable and effective method to treat GDM, SHBG mayalso be a sensitive index to predict the curative effect in early stage.

关 键 词：妊娠期糖尿病 胰岛素抵抗 性激素结合球蛋白 

分 类 号：R714.2[医药卫生—妇产科学]