自然流产妇女血清氧化应激状态分析  

An analysis of oxidative stress in serum of pregnant women with abortion.

作　　者：马秀菊[1] 肖文霞[1] 

机构地区：[1]河北医科大学第二医院妇产科,河北石家庄050000

出　　处：《中国优生与遗传杂志》2006年第5期85-85,116,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的通过对自然流产女妇血清氧化应激指标———超氧化物歧化酶(SOD)、丙二醛(MDA)及维生素E(VE)的测定,分析其氧化应激状态。方法用化学比色法对20例正常未孕妇女、20例正常孕早期妇女及20例自然流产妇女血清中SOD、MDA及VE进行测定。结果与未孕妇女相比,正常孕早期妇女血清MDA升高(P<0.05),SOD和VE也显著升高(P<0.05;P<0.05);与正常孕早期妇女相比。自然流产妇女血清MDA水平升高(P<0.05),SOD、VE水平却下降(P<0.05;P<0.05)。结论自然流产妇女处于氧化应澈状态中。Objective ：To determine the levels of maternal serum SOD, MDA and VE in patients with abortion in order to analyze their oxidative stress. Methods：The levels of maternal serum SOD, M DA and VE were measured in 20 healthy non -pregnant women ,20 normal early pregnant women and 20 patients with abotrion by chemocoiorimetry. Results ：The levels of maternal serum MDA in normal early pregnant Women were significantly higher than those of non - pregnant women （ P 〈 0. 05）, so were the levels of SOD and VE （ P 〈0. 05, P 〈0. 05） ;the levels of maternal serum MDA in patients with abortion were also higher than those of normal early pregnant women（ P 〈0. 05）, while the levels of SOD and VE were significantly decreased（ P 〈0. 05, P 〈0. 05）. Conclusion：The pregnant women with abortion were in oxidative stress.

关 键 词：氧化应激 自然流产 超氧化物歧化酶 丙二醛 维生素E 

分 类 号：R714.21[医药卫生—妇产科学]