注射用谷胱甘肽对慢性病毒性肝炎和中毒性肝炎病人疗效及安全性的临床研究  

The Clinical Studies on the Safety and Efficacy of Glutathione for Injection for Patients with Chronic Viral and Toxic Hepatitis

作　　者：李新芳[1] 侯艳宁[1] 王宝恩[2] 段钟平[3] 崔振宇[4] 王勤环[5] 李莉[6] 王树才[7] 

机构地区：[1]中国人民解放军白求恩国际和平医院国家药品临床研究基地,河北石家庄050082 [2]首都医科大学附属北京友谊医院,北京100050 [3]北京佑安医院,北京100054 [4]北京地坛医院,北京100011 [5]北京大学第一医院,北京100034 [6]中国人民解放军第302医院,北京100039 [7]北京结核病胸部肿瘤研究所,北京101100

出　　处：《解放军药学学报》2006年第2期94-97,共4页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的评价注射用谷胱甘肽对慢性病毒性肝炎和中毒性肝炎病人的临床疗效及安全性。方法122例病毒性肝炎和中毒性肝炎患者随机分为两组,治疗组61例,iv谷胱甘肽1200mg,qd,对照组61例,iv门冬氨酸钾镁3支(每支10ml),qd,开放组42例,iv谷胱甘肽1200mg,qd,疗程4周。结果4周后,治疗组食欲不振、乏力、肝区疼痛、腹胀及黄疸显著减轻(P<0.01)。ALT由(485.91±442.65)U·L-1降到(54.30±39.72)U·L-1(P<0.01);AST由(262.95±288.71)U·L-1下降到(39.68±28.68)U·L-1(P<0.01);总有效率为86.89%。对照组与治疗组类似,总有效率为81.97%(P>0.05)。2组均未发现明显的不良反应。注射用谷胱甘肽治疗的103例,总有效率为92.23%。结论注射用谷胱甘肽治疗病毒性肝炎和中毒性肝炎是安全、有效的。Aim To evaluate the clinical safety and effcacy of glutathione for injection for patients with chronic viraland toxic hepatitis. Methods The 122 patients with chronic viral and toxic hepatitis were selected and randomly dividedinto the treatment group and control group. In the treatment group, patients were intravenous injected with glutathione forinjection 1 200mg qd; in the control group, patients were intravenous injected with potassimn-magnesium aspartate 10ml×3 qd, for 4 weeks. Patients in the open group were administerd with the same drug as the treatment group, Results After 4weeks, in the treatment group, inappetence, debility, liver pain, windy and jaundice significantly decreased （ P 〈 0.01 ）.ALT from （485.91 ± 442.65 ） U·L^-1 decreased to （54.30 ± 39.72） U·L^-1 （ P 〈 0.01 ）. AST from （262.95 ± 288.71 ）U·L^-1 decreased to （39.68 ± 28.68） U·L^-1 （ p 〈 0.01 ）, the clinical efficacy was 86.89 %. The control group （81.97%）resembled the treatment group in clinical efficacy（ P 〉 0.05）.Severe drug reactions of both groups were not discovered. Among the 103 Patients treated with glutathione the clinical efficacy was 92.23 %. Conclusion This result suggests that glutathione for injection is a safe and effective treatment for chronic viral and toxic hepatitis.

关 键 词：谷胱甘肽 门冬氨酸钾镁 慢性病毒性肝炎 中毒性肝炎 

分 类 号：R969.4[医药卫生—药理学]