愈肝胶囊抗大鼠肝纤维化的实验研究  

Anti-fibrosis Effect of Yugan Capsule on Rats with Hepatic Fibrosis

作　　者：高萍[1] 程留芳[1] 谢朝良[2] 邵泽勇 

机构地区：[1]中国人民解放军总医院消化科,北京100853 [2]四川省泸州医学院,四川泸州646000

出　　处：《解放军药学学报》2006年第2期110-112,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的 探讨愈肝胶囊对大鼠实验性肝纤维化的治疗作用。方法 以四氯化碳制备大鼠肝纤维化模型，观察愈肝胶囊对肝纤维化大鼠肝脏病理变化，对肝功能指标ALT、TBIL、ALB、GLO、PT；肝纤维化指标HA、LN、PCⅢ、CⅣ、Hyp及免疫学指标CIM、CD8、CIM／CD8的作用来说明愈肝胶囊对肝纤维化大鼠的影响。结果 愈肝胶囊明显减轻肝纤维化大鼠肝脏的病理改变，改善其肝功能；调节T淋巴细胞；下调肝纤维化4项指标及羟脯氨酸；使肝纤维化程度显著下降，与乙肝宁颗粒组相比有显著性差异（P〈0．05-0．01）。结论 愈肝胶囊有显著降低大鼠实验性肝纤维化反应，增强机体抗肝纤维化损伤能力的作用。Aim To investigate the anti - fibrosis effect of Yugan capsule on rats with hepatic fibrosis. Methods Therats was injected CC14. after their liver became fibrosis, their blood was drew and the liver was taken out, then the pathological change of liver was observed, the indexes of hepatic function an fibrosis were assayed, also CD4, CD8, CD4/CD8 measured by flow cytometry. Results Pathological change of liver, the indexes of hepatic function an fibrosis were improvedby Yugan capsule, which was superior to Yiganning granule（ P 〈 0.05 or P 〈 0.01 ）. Conclusion Yugan capsule canrelieve the reaction of fibrosis of rats with liver injured.

关 键 词：愈肝胶囊 肝纤维化 CD4 CD8 

分 类 号：R965[医药卫生—药理学]