蛋白激酶Ca相互作用蛋白的结构与功能  

The Structure and Function of Protein Interacting with C α Kinase

作　　者：肖虹[1] 袁静明[1] 石亚伟[1] 

机构地区：[1]山西大学生物技术研究所化学生物学与分子工程教育部重点实验室,太原030006

出　　处：《细胞生物学杂志》2006年第2期137-140,共4页Chinese Journal of Cell Biology

基　　金：国家自然科学基金资助项目(No.30400065)~~

摘　　要：蛋白激酶Cα相互作用蛋白(proteininteractingwithCαkinase,PICK1)是蛋白激酶Cα(proteinkinaseCα,PKCα)的靶蛋白之一,也是在PKCα和突触后膜受体蛋白间起重要作用的衔接蛋白。PICK1分别由PDZ结构域、BAR结构域以及卷曲螺旋区和酸性氨基酸区组成。PICK1中的PDZ结构域和受体蛋白、转运蛋白、衔接蛋白的相互作用报道较多,BAR结构域则与支架蛋白、质膜等相互作用。PICK1在突触可塑性、神经递质传递、外周神经感觉、细胞生长和黏连等方面发挥重要作用。本文对PICK1的结构和功能进行综述。Protein interacting with Cα kinase （PICK1） contains a single PDZ domain known to mediate the interaction with several receptors, transporters, ion channels and kinases, and a BAR domain interacted with other proteins and membrane besides PDZ domain itself, as well as a coiled-coil and an acidic amino acid regions. PICK1, as an adaptor protein between protein kinase Cα （PKCα） and receptors at synapse performs its biological function through the interaction with different partners in synaptic plasticity, neurotransmitter regulation, peripheral nervous sensory, cell-cell adhesion and cell growth. In this review, we focus on the structure and function of PICK1.

关 键 词：蛋白激酶Cα相互作用蛋白 PDZ结构域 BAR结构域 功能 结构 

分 类 号：Q51[生物学—生物化学] Q42