端粒酶催化亚单位蛋白及PCNA在尖锐湿疣组织中的表达及意义  

Expression and Significance of hTERT and PCNA Protein in Condyloma Acuminata

作　　者：尹光文[1] 赵卫华[2,3] 张云汉[2] 于建斌[1] 高冬玲[2] 傅世珍[1] 

机构地区：[1]郑州大学第一附属医院皮肤性病科 [2]郑州大学第一附属医院病理科,河南省肿瘤病理重点实验室 [3]广东省惠州市皮肤病医院,广州惠州516000

出　　处：《中国皮肤性病学杂志》2006年第4期196-197,200,共3页The Chinese Journal of Dermatovenereology

摘　　要：目的探讨尖锐湿疣(CA)组织中端粒酶催化亚单位蛋白(hTERT)和增殖细胞核抗原(PCNA)的表达及意义。方法用免疫组化SP法分别检测35例CA组织和18例正常上皮组织中hTERT和PCNA的表达。结果hTERT蛋白在CA组织中阳性29例,阳性率为82.86%,在18例正常上皮中,阳性1例,阳性率为5.56%,二者比较差异有显著性(P<0.01);PCNA在35例CA组织中阳性30例,阳性率85.71%,而18例正常上皮中PCNA阳性率55.56%,PCNA两组阳性率之间差异有显著性(P<0.05);hTERT和PCNA之间的阳性表达呈正相关(r=0.681,P<0.01)。结论hTERT在CA发生、发展中起一定作用,hTERT和PCNA表达呈正相关,表明hTERT与细胞的增殖有关。Objective To detect hTERT and PCNA protein in keratinocytes of Condyloma acuminatum （CA）, and to explore their roles in pathogenesis. Methods hTERT and PCNA protein in 35 cases of CA and 18 normal controls were detected respectively by immunohistochemistry staining（SP）. Results hTERT in CA were significantly higher than those in normal samples（P 〈 0.01 ）, PCNA in CA were significantly higher than those in normal samples （P 〈 0.05 ）, and there was a positive correlation between hTERT and PCNA （ r = 0. 681, P 〈 0.05 ）. Conclusion There is a good correlation between hTERT and PCNA expression, hTERT and PCNA in CA may play some roles in CA pathogenesis.

关 键 词：端粒酶催化亚单位蛋白 增殖细胞核抗原 尖锐湿疣 端粒酶 

分 类 号：R752.5[医药卫生—皮肤病学与性病学] R392.13[医药卫生—临床医学]