L-精氨酸对肾性高血压大鼠主动脉功能的保护作用  

Protective role of L-arginine on aortic function in rats with renal hypertension

作　　者：郭益民[1] 余立群[1] 王颖[1] 张玉青[1] 于建兴[1] 

机构地区：[1]温州医学院生理学教研室,浙江温州325035

出　　处：《温州医学院学报》2006年第2期98-101,共4页Journal of Wenzhou Medical College

基　　金：温州市科学技术委员会基金资助项目(No.00010)

摘　　要：目的:探讨L-精氨酸(L-Arg)对二肾一夹(2K1C)肾性高血压大鼠主动脉内皮功能的影响。方法:雄性SD大鼠术后4w,测量平均动脉压(MAP)、主动脉壁环鸟苷酸(cGMP)含量,并取其主动脉进行离体血管环实验。结果:2K1C大鼠MAP升高,主动脉对乙酰胆碱的舒张反应明显减弱,而对乙酰胆碱的收缩反应显著增强,cGMP含量显著减少。口服L-Arg4w不能降低2K1C大鼠的MAP,主动脉对乙酰胆碱的收缩、舒张反应部分恢复,cGMP含量明显升高。各组大鼠的主动脉环用NOS抑制剂L-硝基-精氨酸甲酯(L-NAME)孵育后,对硝普钠的最大舒张反应无显著不同。结论:L-Arg可能通过增加一氧化氮(NO)的生成,改善2K1C肾性高血压大鼠的主动脉内皮功能。Obdective： To explore the protective role of L-arginine on the function of aortic endothelium function in rats with renal hypertension . Methods：Left renal artery of male SpragrueDawley rats was partially occluded for 4 weeks , mean arterial pressure and cGMPcontent of the aorta were measured,isometric tension changes of aortic rings were recorded . Results：The mean arterial pressure of 2K1C rats was significantly elevated.In isolated aortic rings , acetylcholine-induced relaxation was suppressed , acetylcholine-induced contraction was enhanced,the level of aortic cGMP content was significantly lowered. MAP in 2K1C rats could not be lowered after 4 weeks oral administration of L-arginine, the acetylcholine induced relaxation and contraction responses partiaiiy restored, increased aortic cGMP content markedly.In contrast ,sodium nitroprusside induced maximal relaxation in presence of NG-nitrc-L-arginine methyl ester（L-NAME）did not differ significantly among the three groups. Conclusion：L-Arginine may improve aortic endothelial function of 2K1C renal hypertensive rats through increasing production of NO and decreasing release of contracting factor.

关 键 词：L-精氨酸 一氧化氮 高血压 肾性 主动脉 

分 类 号：R544.1[医药卫生—心血管疾病]