18α-甘草酸和18β-甘草酸抗大鼠肝纤维化作用比较研究  

The comparing study of the anti-hepatofibrosis effect of 18 α-and 18β-Glycyrrhizic acid in rats

作　　者：田静[1] 吕坚[1] 

机构地区：[1]浙江大学药学院,杭州310002

出　　处：《中国现代应用药学》2006年第2期102-104,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的以γ-干扰素(IFN-γ)为阳性对照药,比较研究18α-甘草酸(18α-GL)、18β-甘草酸(18β-GL)的抗大鼠肝纤维化作用。方法以二甲基亚硝胺(DMN)腹腔注射诱导大鼠肝纤维化模型,染毒开始及染毒后5周分别用18-αGL,18-βGL,IFN-γ预治疗和治疗肝纤维化。观察各组肝羟脯氨酸(HyP)、血清透明质酸(HA)水平,血清生化指标、病理及肝纤维化程度。结果与IFN-γ比较,18-αGL,18β-GL差相异构体预治疗组和治疗组抗肝纤维化作用与其相近,治疗组明显优于染毒对照组;18α-GL治疗组明显优于18β-GL组。结论18-αGL,18β-GL差相异构体有较好的抗肝纤维化作用,且18α-GL明显优于18β-GL。OBJECTIVE To compare the anti-hepatofibrosis effeα of 18 α-glycyrrhizic acid （ 18 α-GL） and 18β-glycyrrhizic acid （ 18β-GL） in rats ,using γ-interferon （IFN-γ） as the positive drug. METHODS The rat models of hepatic fibrosis induced by abdomen injeαion of dimethyl nitrosamine （DMN） were applied, 18 α-GL, 18β-GL and IFN-γ were used to pre-cure and cure the hepatic fibrosis in different stages. Then,the HyP,levels of HA,the liver funαion of serum,the pathology and the degree of hepatic fibrosis in different groups were observed. RESULTS The anti-hepatofibrosis effect in 18α-GL, 18β-GL pre-eured groups and the cured groups was close to that of in the IFN-γ pre-eured and cured groups ,the effect in each of the cured groups was obviously better than that of in the DMN controlled groups,and the effect in 18 α-GL cured groups was obviously better than that of in 18β-GL cured groups. CONCLUSION 18 α-glyeyrrhizie acid and 18β-glyeyrrhizie acid have shown nice anti-hepatofibrosis effect,moreover the effect of 18 α-GL is obviously better than that of 18β-GL.

关 键 词：18Α-甘草酸 18Β-甘草酸 肝纤维化 二甲基亚硝胺 

分 类 号：R969.4[医药卫生—药理学] R575.2[医药卫生—药学]