微生物比浊法与管碟法测定磷霉素钠效价的评价  

The comparison of the titer of fosfomycin sodium by turbidimetry and cylinder-plate method

作　　者：赵晓冬 张亚杰 傅蓉[2] 邢志强[3] 

机构地区：[1]辽宁省药品检验所抗生素室,沈阳110023 [2]沈阳药科大学制药工程学院,沈阳110016 [3]辽宁大学分析测试中心,沈阳110036

出　　处：《实用药物与临床》2006年第2期75-76,共2页Practical Pharmacy and Clinical Remedies

摘　　要：目的验证比浊法测定磷霉素钠效价方法的可行性。方法应用比浊法测定磷霉素钠含量,并对微生物比浊法、管碟法测定磷霉素钠效价的结果进行评价。结果比浊法、管碟法效价测定结果一致。结论比浊法测定磷霉素钠效价快速、可行,对中间产品的检验更具有重要意义。Objective To verify the feasibility of a method for determining the titer of fosfomycin sodium by turbidimetry. Methods To constitute a method to determine the titer of fosfomycin sodium by turhidimetry, and compare the result determined by turbidimetry with that by cylinder-plate method. Results The result of turbidimetry was consistent with that of cylinder-plate method. Conclusion The titer of fosfomycin sodium determined by turbidimetry is rapid and feasible, and it is more significant to verify the semifinished product.

关 键 词：比浊法 管碟法 磷霉素钠 含量测定 

分 类 号：R927[医药卫生—药学]