美托洛尔注射液治疗快速心房纤颤临床疗效观察  

Therapeutic efficacy evaluation of intravenous metoprolol in patients with rapid atrial fibrillation

作　　者：郑强[1] 韩峰[2] 韩新飞[1] 臧彬[1] 

机构地区：[1]中国医科大学附属第二医院急诊科,沈阳110004 [2]中国医科大学附属第二医院药剂科,沈阳110004

出　　处：《实用药物与临床》2006年第2期90-92,共3页Practical Pharmacy and Clinical Remedies

摘　　要：目的观察美托洛尔注射液治疗快速房颤的有效性和安全性。方法将66例符合入选标准的快速房颤患者随机分为2组,美托洛尔组(34例):美托洛尔5 mg缓慢静脉注射,观察5 min,如无效重复一次,连续用药3次,总量15 mg;西地兰组(32例)为对照组:西地兰0．2-0．4 mg稀释后静脉注射,观察10 min,如无效追加0．2-0．4 mg,连续用药3次,总量0．6-1．0 mg。记录用药前后心室率和血压变化,并比较在各观察时间点上的有效率。结果美托洛尔与西地兰相比,起效更快[(8．7±3．2)min vs(38．4±10．1)min],心室率下降幅度明显(35．44％ vs 27．04％),治疗有效率更高(91．2％ vs 71．9％),无严重不良反应发生。结论美托洛尔注射液控制快速房颤心室率快速、安全、有效。Objective To observe the efficacy and safety of intravenous metoprolol for control of ventricular rate in patients with atrial fibrillation. Methods 66 eligible patients with atrial fibrillation were randomized to 2 groups, metoprolol group（n = 34） ：5 mg was injected slowly. If there is no effect in 5 minutes, it must be done again for 3 times consecutively, and the total dose was 15 mg;Cedilanid group（control group, n = 32） ：0.2 - 0,4 mg was injected after diluted, If non- efficacious, it can be given 0.2 - 0.4 mg again for 3 times consecutively, and the total dose was 0.6 1.0 mg. Electrocardiographic recordings and blood pressure were performed before and after drug administration. Compare the efficacy at different time points. Results Compared with the cedilanid group, metoprolol took effect faster [ （8.7 ± 3.2）min vs （38.4 ± 10.1 ） min], significantly decreased in ventricular rate （ 35.44 % vs 27.04 96 ）, and had a higher total effective rate （91.2 % vs 71.9 % ）. All patients improved without any severe side effect. Conclusion To control ventricular rate of rapid atrial fibrillation by intravenous metoprolol is rapid, safe, and efficacious.

关 键 词：房颤 美托洛尔 静脉注射 

分 类 号：R541.75[医药卫生—心血管疾病]