豚鼠心脏CDP-乙醇胺磷酸转移酶的动力学研究  

The kinetic study of CDP-ethanolamine phosphotransferase in guinea pig heart

作　　者：吕俊[1] 吕灿群[1] 

机构地区：[1]皖南医学院生物化学教研究,芜湖241001

出　　处：《生物学杂志》2006年第2期25-27,64,共4页Journal of Biology

基　　金：安徽省教育委员会自然科学研究基金(97JL158)资助课题

摘　　要：为探讨不同的二价基甘油对三种乙醇胺甘油磷脂生物合成能力的影响,通过对豚鼠乙醇胺磷酸转移酶动力学研究,发现磷脂酰乙醇胺的合成可被1-烷基-2-脂酰甘油和1-烯醚基-2-脂酰甘油抑制,而缩醛磷脂酰乙醇胺的生成不受1,2-二脂酰甘油影响,并提示不同的二价基甘油对乙醇胺磷酸转移酶的抑制作用呈非竞争性抑制,此有利于对三种乙醇胺磷脂酰甘油生物合成的相互协调作用。The effect of different diradylglycerol on three ethanolamine glyceropholipids biosynthesis ability was studied by means of kinetic study on ethanolamine phosphotransferase in guinea pig heart. The results revealed that the synthesis of phosphatidylethanolamine was inhibited by 1 - alkyl - 2 - acyl glycerol and alkenyl - 2 - acylglycerol, but the formation of plasmenylethanolamine was not affected by 1,2 - diaeylglycerol, and revealed the inhibition of different diradylglycerol for ethanolamine phosphotranferase appeared a noncompetitive inhibition in favor of the mutual coordination for three ethanolamine glycerophosphlipid biosynthesis.

关 键 词：乙醇胺磷酸转移酶 动力学研究 非竞争性抑制 二价基甘油 

分 类 号：Q591.9[生物学—生物化学]