济南地区献血者中人疱疹病毒8型(HHV-8)IgG抗体的检测及相关危险因素分析  

Prevalance of human herpesvirus 8(HHV-8)IgG and its associated risk factors in blood donors from Jinan region

作　　者：齐眉[1] 赵蔚明[1] 周亚滨[1] 栾怡[1] 卞继锋[1] 王红[1] 程轶喆[1] 刘娟[1] 唐伟[1] 于晗[1] 

机构地区：[1]山东大学医学院微生物学教研室,山东济南250012

出　　处：《山东大学学报（医学版）》2006年第4期328-331,共4页Journal of Shandong University:Health Sciences

基　　金：山东大学校青年基金资助课题(21300050190002)

摘　　要：目的:了解人疱疹病毒8型(HHV-8)在济南地区不同献血者中的感染情况,并对其与年龄、性别、HBV、HCV、梅毒螺旋体的相关性进行统计学分析。方法:以HHV-8 ORF K8.1合成多肽为抗原,采用ELISA方法检测献血者血清中相应IgG水平。结果:520份血清中抗HHV-8 ORFK8.1抗体的总体检出率为5.962%(31/520),有随年龄增加而增高的趋势,但与性别、HBV、HCV、梅毒螺旋体的相关性无统计学意义。结论:济南地区献血者中有一定比率的HHV-8感染。采取措施,防止HHV-8经输血传播具有一定的现实意义。Objective： To estimate the seroprevalence of HHV-8 infection and its correlation with hepatitis B virus （HBV）, hepatitis C virus （HCV） and syphilis infection among blood donors in Shandong region. Method： Five hundred and twenty serum were tested for HHV-8 IgG antibody with ELISA by using HHV-80RF K8.1 peptides as antigen. Results： The mortality of positive HHV-8 IgG antibody in blood donors from Jinan region was 5.962% （31/520）, and had a trend of increase with the blood donors＇ increasing age, but it was not associated with exposure to HBV, HCV or syphilis. Conclusion： There is a certain rate of HHV-8 infection in blood donors of Shandong. It is necessary to screen blood donors for HHV-8.

关 键 词：献血者 人疱疹病毒8型 免疫球蛋白G 

分 类 号：R373.9[医药卫生—病原生物学]