城乡地区临床分离真菌菌种类型调查及其耐药谱比较  

Analysis and comparison:species distribution and drug resistance of pathogens seperated from clinical fungus infection in rural and urban areas

作　　者：农生洲[1] 刘先洲[1] 

机构地区：[1]武汉大学医学院

出　　处：《广西医学》2006年第2期187-189,共3页Guangxi Medical Journal

基　　金：广西壮族自治区自然科学基金资助项目(桂科青0135017)

摘　　要：目的了解广西城乡地区临床分离致病性真菌的菌群分布特征及其对常用抗真菌药物的耐药现状。方法收集136所广西各地医院就诊病人不同部位真菌培养阳性标本所分离到真菌,应用CHROMagar念株菌显色培养基和ATB ID32试条进行菌种鉴定,ATB FUNGUS试条进行体外药敏试验研究。结果城市地区医院致病性真菌的分离率占感染性疾病病原体(细菌+真菌)总数的15·55%,分离出的菌种类共26种,农村地区则相应为6·51%和21种;分离率占前四位菌种城乡地区相同,依次为白色念珠菌、热带念珠菌、光滑念珠菌和近平滑念珠菌,分别占总数的83·0%和92·0%。对5-氟胞嘧啶等6种常用抗真菌药物的体外药物敏感试验,城市医院的耐药率分别为17·33%、25·87%、25·17%、33·05%、62·24%、57·33%。农村地区医院分别为10·65%、10·90%、11·03%、23·57%、36·23%、31·63%。结论广西城乡地区临床深部真菌感染率均较高,城市地区感染状况较农村地区严重(P<0·01)。临床标本分离的病原性真菌种类和分布状况城乡地区基本相似;城市医院临床标本分离的病原性真菌对常用抗真菌药物的耐药率较基层医院高(P<0·01)。Objective To investigate the distribution and drug resistance of pathogens seperated from clinical fungus infection in rural and urben areas, Methods Collecting the pethogens isolated from clinical infectious specimens of 136 hospitals （103 in rural, 33 in urban）, pathogens identified were tested by ATB expression and CHROMagar Media. Susceptibility tests were perfomed by using ATB FUNGUS.Results ① The percentage of fungus isolated from clinical infectious specimens was 15.55% （bacterium plus fungus） in urban areas, 6.51% in rural areas . ②In urban areas, 26 species were identified from clinical fungus infection, common pathogens were Candida albicans （52.65 % ）, Candida tropicalis （ 15.69 % ）, Candida glabrata （9.65 % ）, Candida parapsilosis （4.96 % ）. In rural areas, correspondingly, were 21 species, with Candida albicans accounting for 53.32%, Candida tropicalis 20.70%, Candida glabrata 11.41%, and Candida parapsilosis 6.36% . ③The rate of drug resistance to 6 common drug were 17.33%,25.87%,25.17%, 33.05%,62.24%,57.33% in urban areas; in rural areas, correspondly, were 10.65%,10.90%,11.03%,23.57%,36.23%, 31.63 %. Conclusion The rate of fungus infection in urben areas is more severe than in rural areas in Guangxi （P 〈 0.01） ; It is almost the same species and distribution of the pethogens of fungus infection from both hospitals of rural areas and urban areas. The rate of drug resistance of pethogenic fungus from urban hospitals were higher than the one from rural hospitals（P〈0.01）.

关 键 词：真菌 病原体 药敏试验 耐药谱 

分 类 号：R519[医药卫生—内科学]