氧化苦参碱对冠心病患者心律失常及心率变异性的影响  

Therapeutic Efficacy of Oxymatrine on Arrhythmia and Heart Rate Variability in Patients with Coronary Heart Disease

作　　者：郭治彬[1] 付金国[1] 赵勇[1] 刘睦胜[1] 李青[1] 

机构地区：[1]南昌大学第一附属医院心血管内科,南昌330006

出　　处：《中国中西医结合杂志》2006年第4期311-315,共5页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：江西省卫生厅科技计划资助课题(No.0301027)

摘　　要：目的应用动态心电图和心率变异性指标评价氧化苦参碱对冠心病患者心律失常及心率变异性的影响。方法将冠心病频发心律失常患者110例随机分为氧化苦参碱组和普鲁帕酮组,每组各55例,用药前后分别记录48h动态心电图,评价患者一般状态、早搏次数,PR间期、RR间期及24h心率变异性指标的改变。结果用药后两组患者对房性和室性心律失常均有效(P<0.01),普鲁帕酮组减少房性早搏的效果比氧化苦参碱组更明显(P<0.05),两组减少室性早搏的效果比较差异无显著性(P>0.05),两组治疗后心率变异性各参数较治疗前均显著升高(P<0.01),两组治疗后比较差异有显著性(P<0.05)。结论氧化苦参碱可以显著提高冠心病心律失常患者心率变异性,对于房性和室性心律失常均有显著疗效。Objective To evaluate the therapeutic efficacy of oxymatrine （Oxy） on arrhythmia and heart rate variability （HRV） in patients with coronary heart disease （CHD） by Holter electrocardiogram and HRV indexes. Methods One hundred and ten patients with CHD and frequent arrhythmia were randomly divided into the Oxy group and the propafenone group, 55 cases in each group. Changes of general conditions, 48 hrs Holter electrocardiogram, frequency of premature beats, P-R interval, R-R interval and 24 hrs HRV index in patients before and after treatment were evaluated. Results The amount of both atrial and ventricular premature beats decreased markedly in both groups （P 〈 0.01 ）. Propafenone showed better effect in reducing atrial premature beats than that of Oxy （ P 〈 0.05 ）, while the two had similar effect on ventricular premature beats （ P 〉 0.05）. HRV was elevated in both groups after treatment （P 〈 0.01 ）, but the effect of Oxy was superior to that of propafenone after treatment （P 〈 0.05）. Conclusion Oxymatrine could significantly improve HRV, and shows obvious effects on atrial and ventricular arrhythmia in patients with CHD.

关 键 词：氧化苦参碱 普鲁帕酮 心律失常 心率变异性 

分 类 号：R259.4[医药卫生—中西医结合]