中药艾灵颗粒对HIV/AIDS患者免疫重建的影响  

Effects of Ailing Granule on Immuno-reconstruction in HIV/AIDS Patients

作　　者：危剑安[1] 孙利民[1] 陈宇霞[1] 薛柳华[1] 苏小游[2] 黄霞珍[1] 白文山[1] 宋春鑫[1] 周伟[1] 金燕[1] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]中国疾病预防与控制中心

出　　处：《中国中西医结合杂志》2006年第4期319-321,共3页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助项目(No.30371822)

摘　　要：目的拟通过对艾滋病感染/艾滋病(HIV/AIDS)患者进行益气活血中药的干预,初步探索益气活血中药艾灵颗粒治疗艾滋病的可能作用机理。方法21例HIV/AIDS患者采用益气活血中药艾灵颗粒(主要由女贞子、黄芩、黄芪、土鳖虫等组成)治疗,每次20g,每日2次,疗程4个月,记录治疗前后症状、体征积分,以流式细胞技术检测其T细胞亚群(CD3、CD4、CD8)、白细胞介素2(IL2),以RTPCR法测定病毒载量,并检测安全性指标(ALT、Cr、体重)。结果治疗后症状、体征积分较治疗前下降,其中乏力、纳呆、自汗、皮疹差异有显著性(P<0.05),有效率为61.9%;CD4计数和IL2分别由治疗前的(308.29±150.66)个/μl和(13.19±5.93)ng/L升高为治疗后的(336.50±148.94)个/μl和(15.14±5.14)ng/L(P<0.05),病毒载量虽有下降,但差异无显著性;安全性指标(ALT、Cr、体重)均保持稳定(P>0.05)。结论益气活血中药艾灵颗粒可显著改善艾滋病患者的症状,提高免疫功能,并在一定程度上抑制HIV的复制,或使其处于稳定状态,且未见明显毒副反应。Objective To explore the possible mechanism of Ailing Granule （AG, a Chinese herbal preparation for nourishing Qi and activating blood circulation） in intervening HIV/AIDS. Methods Twenty-one HIV/AIDS patients were orally administered with AG （mainly composed of Fructus Ligustri lucidi, Radix Scutellariae, Radix Astragalus and Eupolyphaga et polyphage） by 20g, twice a day for 4 months. Their symptoms and signs were scored, T cell subgroup （CD3, CD4, CDs） and interleukin-2 （IL-2） were detected with flowcytometry, and viral load determined with RT-PCR, as well as some indexes for safety evaluation, including ALT, Cr and BW were observed before and after treatment. Results After treatment, the symptom and sign score of patients lowered, among them the scores of fatigue, anorexia, spontaneous sweating and skin rash reduced with difference statistically （P 〈 0.05） ; the total effective rate was 61.9 % ; CDo count and IL-2 level increased from 308.29 ± 150.66/μl and 13.19 ±5.93 ng/L to 336.50±148.94/μl and 15.14± 5.14 ng/L respectively（P 〈 0.05） ; while the viral load lowered but showed no significant difference. All the indexes of safety measured kept unwavering during treatment（P 〉0.05）. Conclusion AG could significantly alleviate the symptoms of HIV/AIDS patients, improve their immune function, inhibit HIV reproduction to a certain extent or keep it stable. No obvious toxic or adverse reaction was seen.

关 键 词：益气活血中药 艾滋病感染/艾滋病 免疫重建 白细胞介素-2 

分 类 号：R259[医药卫生—中西医结合]