维持性血透慢性肾功能不全患者血浆内皮素观察  

Plasma Endothelin Level in Maintained Hemodialysis With Chronic Renal Insufficiency

作　　者：辜旭辉[1] 王季猛 

机构地区：[1]衡阳医学院第二附属医院

出　　处：《衡阳医学院学报》1996年第1期26-28,共3页

摘　　要：本文对２１例维持性血透慢性肾功能不全患者及１６例健康人进行了内皮素（ＥＴ）水平的测定。维持性血透慢性肾功能不全患者，无论透析前后，血浆ＥＴ水平均较正常人明显增高，但透析后ＥＴ水平下降。平均ＥＴ浓度从透前２１２．６８±１１９．７ｐｇ／ｍｌ（±ｓ）下降至１１３．００±６８．７ｐｇ／ｍｌ（Ｐ＜０．０１）。健康对照者ＥＴ水平明显低于血透者（４９．６８±２３．７ｐｇ／ｍｌ）。维持性血透慢性肾功能不全患者透析前、后ＥＴ水平与健康对照组相比均有明显差异（Ｐ＜０．００１和Ｐ＜０．０５）。本文对透析前后血浆ＥＴ与血压及超滤量的关系进行了分析。Plasma immunoreactive endothelin ( ET) concentration was measured in twenty-one maintained hemodialysis patients with chronic renal insufficiency and sixteen normal control subjects.In maintained hemodialysis with chronic renal insufficiency, the plasma ET level rose, but fell after a period of hemedialysis.Mean predialysis concentration decreased from 212.68± 119.7 pg/ml(x±s)to 113.00±68.7 pg/ml.In normal subjects,the plasma ET level was low (49. 68±23.7 pg/ml).The comparison of ET level between normal subjects and patients with chronic renal insufficiency includingpredialysis and postdialysis was significantly different(respectively P<0.001 and P<0.05).

关 键 词：内皮素 血液透析 肾功能不全 

分 类 号：R692.505[医药卫生—泌尿科学]