受试者特征曲线评价妊娠相关血浆蛋白A在急性冠状动脉综合征早期诊断中的价值  

ROC curve estimates the value of pregnancy associated plasma proteinA for the early detection of acute coronary syndrome

作　　者：孙玉发[1] 范利[1] 冯胜强[2] 蒋知新[3] 郭广宏[4] 原新红[4] 缴富斌[2] 

机构地区：[1]解放军总医院老年心内科,北京100853 [2]总参警卫局保健处 [3]解放军第305医院 [4]解放军总医院生化科,北京100853

出　　处：《中国临床保健杂志》2006年第2期111-113,共3页Chinese Journal of Clinical Healthcare

摘　　要：目的探讨外周血炎症标志物妊娠相关血浆蛋白A(PAPP-A)在急性冠状动脉综合征(ACS)早期诊断中的应用价值。方法测定60例ACS患者发病12 h内的外周血PAPP-A与超敏C-反应蛋白(hs-CRP),并同时测定30例稳定型心绞痛与30例健康志愿者PAPP-A与hs-CRP作对照,描绘相应的受试者特征(ROC)曲线并进行ROC曲线分析。结果PAPP-A在AMI组和UA组ROC曲线下面积(AUC)分别为(0.890±0.034)(、0.854±0.049),均大于hs-CRP(分别为0.759±0.050、0.781±0.040)。PAPP-A在ACS组的ROC曲线下面积(0.872±0.030)亦大于hs-CRP(0.770±0.042)。结论PAPP-A较hs-CRP具有更好的ACS诊断价值,有望成为新的ACS早期诊断的炎性标志物。Objective To estimate the value of pregnancy associated plasma protein A for early diagnosis of acute coronary syndrome. Methods The study included 30 AMI patients （23 male, 7 female）, 30 UA （22 male, 8 female）, 30 SA （22 male, 8 female） and 30 healthy cases （25 male, 5 female）. Blood samples from AMI and UA patients were obtained at（9.6±3. 9）hours and （8.6±4. 0）hours after the onset of symptoms respectively. The serum levels of PAPP-A and high-sensitive C-reactive protein were measured at the same time. Results Areas of PAPP-A under the receiver operating characteristic （ROC） curves in AMI and UA were （0. 890±0. 034） and （0. 854±0. 049）, greater than that of hs-CRP （0. 759±0. 050, 0. 781±0. 040） respectively. Area of PAPPA under ROC curve in ACS （0. 872±0. 030） was also greater than that of hs-CRP （0. 770±0. 042）. Conclusion PAPPA seems to be superior to ACS than that of hs-CRP of diagnostic value for the Acs, which may be a new inflammatory marker for ACS early diagnosis.

关 键 词：冠状动脉疾病 妊娠相关血浆蛋白A ROC曲线 早期诊断 

分 类 号：R541.4[医药卫生—心血管疾病]