特发性血小板减少性紫癜患者抗心磷脂抗体的检测  

Detect of Anticardiolipin Antibody in Patient with Idiopathic Thrombocytopenic Purpura

作　　者：于超[1] 徐成伟[1] 姜翠英[1] 

机构地区：[1]山东大学第二医院检验科,济南250033

出　　处：《血栓与止血学》2006年第2期73-74,共2页Chinese Journal of Thrombosis and Hemostasis

摘　　要：目的了解抗心磷脂抗体(ACA)与特发性血小板减少性癜(ITP)的关系。方法采用 ELISA 法检测 ACA-IgG,ACA-IgM。结果 30例 ITP 患者 ACA-IgG 阳性率为70%(21例),其中高滴度(index value≥2.2)50%(15 例)；IgM 阳性率为56.7%(17例),高滴度20%(6例)。20例健康对照组 ACA-IgG 阳性率5%(1例),IgM 阳性率5% (1例)。结论 ITP 患者 ACA-IgG 和 ACA-IgM,尤其是高滴度 ACA-IgG 对 ITP 的诊断有一定临床意义。Objective To investigate the relationship between anticardio lipin antibody and idiopathic thromboeytopenie purpura（ITP）. Methods Detecting ACA-IgG, ACA-IgM with ELISA methos. Results The positive rates of ACA-IgG and ACA-IgM are 70% and 56.7% respectively in 30 cases of ITP patients. The positive ACA-IgG with high concentration（ index value 〉2.2） is 50%. The positive rates of ACA-IgG and ACA-IgM are both 5% respectively in normal control, Conclusion The positive rates of ACA-IgG and ACA- IgM in ITP are higher than those in normal control significantly（ P 〈 0.01 ）. The detection of ACA-IgG, IgM and ACA-IgG with high concentration especially has certain clinical value in the diagnosis of ITP.

关 键 词：抗心磷脂抗体 特发性血小板减少性紫癜 

分 类 号：R446.5[医药卫生—诊断学]