绞股蓝多糖（GPS）生物学作用的研究  

Study on Biological Effects of Gynostemma Pentaphyllum Makino Polysaccharide (GPS)

作　　者：娄振岭[1] 马丽萍[1] 张晓琴 苗健[1] 

机构地区：[1]河南医科大学食管癌研究室

出　　处：《河南肿瘤学杂志》1996年第3期168-170,共3页Henan Journal of Oncology

摘　　要：本文报道绞股蓝多糖（ＧＰＳ）的生物学作用──抗氧化作用、细胞免疫促进作用。实验结果表明：①ＧＰＳ５ｍｇ／只／天灌胃，能降低正常小鼠脂质过氧化（ＬＰＯ）水平（Ｐ＜０．０５），能提高正常小鼠超氧化物歧化酶（ＳＯＤ）活性（Ｐ＜０．０５）。②ＧＰＳ５０ｍｇ／只／天灌胃，能显著降低亚急性衰老模型小鼠脂质过氧化水平（Ｐ＜０．０１），能显著提高亚急性衰老模型小鼠超氧化物歧化酶活性（Ｐ＜０．０１），③ＧＰＳ具有显著的细胞免疫促进作用。小鼠自由饮用ＧＰＳ１ｇ／ｄｌ，２０天后脾细胞增殖反应，腹腔巨噬细胞补体Ｃ３ｂ受体及巨噬细胞吞噬功能均显著提高（Ｐ＜０．０１）。Great attention was paid to Gynostemma Pentaphyllun Makino (cucurbitaceae) as containing ginsenoside and having panax effects. By now, the study on the biological effects of the active principle on the Gynostemma Pentaphyllum Makino has not been reported except the Gypenosides. The biological effects of Gynostemma Pentaphyllum Makino Polysaceharide GPS reported here include their antioxidation and immunopotentiation. The experimental results indicated that ①GPS (oral 5mg a day ) could decrease the lipoperoxied of lipied (LPO) level and increase the activity of the superoxide dismutate (SOD) in the normal mice, (P<0.05) ②GPS (oral sing a day) could strikingly decrease the LPO level of lipide (P<0.01),and obviously increase the SOD activity in subacute senium mice. (P<0.01)③ GPS had remarkable cellular immunologic function. The proliferation reaction of splenocytes, the macrophage C3b recepter and macrophage function were significantly improved(p <0.01).

关 键 词：绞股蓝 绞股蓝多糖 SOD 免疫学 脂质过氧化 

分 类 号：R979.1[医药卫生—药品]