哮喘患儿血清IL-4、TNF-α与IgE水平的探讨  

Discussion the level of IL-4,TNF-α and IgE in the secure of children asthma patients.

作　　者：王艳丽[1] 刘君炎[1] 王莹[2] 陈和斌[2] 

机构地区：[1]武汉大学医学院免疫学系 [2]武汉市儿童医院呼吸科,武汉430016

出　　处：《华中医学杂志》2006年第2期118-119,共2页Central China Medical Journal

摘　　要：目的探讨IgE、IL-4与TNF-α在儿童哮喘发病中的作用以及IgE与IL-4的相关性。方法采用酶联免疫吸附试验检测哮喘发作期40例、缓解期30例患儿及健康对照30例儿童IL-4、TNF-α水平和IgE水平。结果哮喘组的IgE、IL-4与TNF-α水平均较对照组高,且发作期与缓解期、缓解期与对照组比较均有极显著性差异(P<0.01)。IgE与IL-4呈正相关。结论IgE、IL-4和TNF-α在儿童哮喘发病中起着重要作用,而且与哮喘的病情有一定的关系。Objective To explore IgE,IL-4 and TNF-α play a role in pathogenesy of allergic bronchial asthma and relationship between IgE and IL4. Method To detect the level of IgE, IL-4, TNF-α by enzyme linked immunnosorbent assay （ELISA） in allergic bronchial asthma（n =40）, catabasis bronchial asthma（n = 30） and control group（n = 30） Result Significant elevation of IgE, IL-4 and TNF-α in allergic bronchial asthma groups as compared with that in control group was observed, there＇s significant difference not only between attack and remission stage, but also between remission stage and control. IgE and IL-4 show positive correlation. Conclusion Data suggests that IgE, IL-4 and TNF-α play a very important role in allergic bronchial asthma, as well they have relationship with the disease.

关 键 词：哮喘 免疫球蛋白E 白细胞介素-4 肿瘤坏死因子Α 

分 类 号：R725.6[医药卫生—儿科]