7-氨基头孢烷酸生产中三甲基一氯硅烷的回收  

Recovery and Use Trimethylchlorosilane During Manufacture of 7-Aminocephalosporanic acid

作　　者：王鹏辉[1] 王建忠[1] 邱增会 邓凯顺[1] 

机构地区：[1]石药集团河北中润制药有限公司,河北石家庄050041

出　　处：《河北化工》2006年第4期38-39,共2页Hebei Chemical Industry

摘　　要：7-氨基头孢烷酸(7-ACA)是生产头孢类抗生素的重要中间体,在其生产过程中使用三甲基一氯硅烷和二甲基二氯硅烷进行羧基保护,反应后可以生成六甲基二硅氧烷(MM)等一系列产物,经回收六甲基二硅氧烷并使用氯化氢法合成三甲基一氯硅烷,达到三甲基一氯硅烷回收再利用的目的,回收率可达60%以上。合成的三甲基一氯硅烷应用于7-ACA生产,对7-ACA的收率和质量均无影响,能够完全满足7-ACA的生产需要。7-Aminocephalosporanic acid is one of most important intermediates when manufacturing cephalosporin and usually uses trimethylchlorosilane and dimethyldichlorosilane to protect carboxyl. A series of hexamethyldisiloxane etc. can be formed at the end of reactions,and reclaim hexamethyldisiloxane and uses hydrogen chloride to produce trimethylchlorosilane from hexamethyldisiloxane by synthesize, yields is over 60%. We considered it to be not influence on the quality and yield of 7-ACA by using the trimethylchlorosilane and the quality and yield of 7-AEA accord with our company standard.

关 键 词：7-氨基头孢烷酸 六甲基二硅氧烷 三甲基一氯硅烷 氯化氢法 

分 类 号：TQ465.1[化学工程—制药化工]