同种异体胰腺组织微块移植治疗糖尿病小鼠的研究  

Study on Homologous Pancreatic Tissue Paticulate Transplantion from Different Body Treating Diabetes Mellitus in Mice

作　　者：赵晓唐[1] 刘永平[1] 张红艳[1] 刘春燕[1] 张园[1] 李志红[2] 赵朝贤[1] 

机构地区：[1]河北工程大学医学院生物化学系,河北邯郸056029 [2]邯郸钢铁集团医院儿科,河北邯郸056000

出　　处：《实用儿科临床杂志》2006年第8期493-493,502,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨同种异体胰腺组织微块移植对糖尿病(DM)小鼠的治疗效果及移植物在宿主体内的存活情况。方法把海藻酸钠微囊包被的正常KM小鼠胰腺组织微块移植入链脲佐菌素诱导的DM小鼠腹腔,连续监测空腹血糖(FPG)水平。结果海藻酸钠微囊包被的胰腺组织微块可有效降低DM小鼠的FPG,且移植物在宿主体内可存活12 d以上。结论海藻酸微囊包被的胰腺组织微块移植在DM治疗中有应用潜能。Objective To discuss the curative effect of homologous panscreatic tissue particulate transplantion on diabetes mellitus （DIM） and their survival in host. Methods Sodium alginate microencapsuled pancreas of normal KM mice were transplanted into abdominal cavity of DM mice. Then fasting ,plasma glucose（FPG） was observed continuously. Result Sodium alginate mieroencapsuled pancreas decreased the FPG of DM mouse and the transplant survived for over 12 days in host. Conclusion It is promising to use microencapuled pancreas transplantion to treat DM.

关 键 词：海藻酸钠 微囊 胰腺组织微块 移植 糖尿病 

分 类 号：R657.5[医药卫生—外科学]