慢性阻塞性肺病患者动脉血碳氧血红蛋白含量的变化  

The Changes of Arterial Carboxyhemoglobin Concentrations in Patients with Chronic Obstructive Pulmonary Disease

作　　者：耿铭[1] 

机构地区：[1]首都医科大学附属北京友谊医院呼吸内科

出　　处：《首都医科大学学报》2006年第2期239-240,共2页Journal of Capital Medical University

摘　　要：目的研究慢性阻塞性肺疾病(COPD)患者在急性期和缓解期体内动脉血碳氧血红蛋白(Hb-CO)含量的变化,以及与吸烟的关系。方法对52名COPD患者(32名有吸烟史,20名无吸烟史)在急性发作期和缓解期进行动脉血气分析,比较Hb-CO含量的变化以及与吸烟的关系。结果急性发作期的慢阻肺患者动脉血Hb-CO含量高于缓解期(P<0.01);有吸烟史的患者体内动脉血Hb-CO含量高于非吸烟者(P<0.01)。结论COPD患者特别是有吸烟史的病人急性发作期Hb-CO含量增高,可能与氧化抗氧化系统平衡调节有关。Objective Arterial blood carboxyhemoglobin concentrations （Hb-CO） increase in acute inflammatory pulmonary diseases. To investigate whether arterial Hb-CO is useful to monitoring disease severity in patients with chronic obstructive pulmonary disease （COPD） who have history of smoking. Methods We measured arterial Hb-CO, arteriovenous Hb-CO differences in 32 patients who smoking history with COPD and 20 non-smoking subjects. To analyze the changes of arterial blood carboxyhemoglobin concentrations, and study the relationship of that changes to patients＇ stages. Results Arterial Hb-CO concentrations increased in acute stage of patients with COPD（P〈0.01）, it was higher in subjects who had smoking history than that without smoking （P〈0.01）. Conclusion These findings suggest that the increased arterial Hb-CO may relate to severity in patients with COPD because of lung and systemic inflammation and production of reactive oxygen species.

关 键 词：碳氧血红蛋白 慢性阻塞性肺疾病 吸烟 

分 类 号：R563.4[医药卫生—呼吸系统]