心肌细胞上的KCNK通道  

KCNK Channels in Cardiac Myocytes

作　　者：麻涛[1] 王军[1] 钮伟真[1] 

机构地区：[1]首都医科大学基础医学院生理学教研室

出　　处：《首都医科大学学报》2006年第2期275-278,共4页Journal of Capital Medical University

基　　金：北京市教委科技发展计划(KM200510025001);北京市自然科学基金(7052012)资助项目

摘　　要：KCNK通道是一类新型的钾离子通道,具有4个跨膜片断和2个膜孔区。它广泛分布于兴奋和非兴奋组织中,在心肌细胞上主要为TWIK、TASK和TREK。此类通道对经典的钾通道阻断剂并不敏感,机械刺激、不饱和脂肪酸、pH、吸入性麻醉剂等因素则可影响其活动。KCNK通道可能作为背景钾通道,在调节心肌细胞动作电位平台期的时程、幅度及静息电位维持等方面有重要作用。KCNK channels are new types of potassium channels which have four transmembrane segments and two pore domains. They are widely distributed in excitable and non-excitable tissues. There are three kinds of them in heart, including TWIK, TASK and TREK. KCNK channels are not sensitive to some classical blockers of potassium channels, but mechanical stimuli, unsaturated fatty acid, pH and volatile anesthetics can regulate their activities. KCNK channels, acting as background potassium channels in cardiac myocytes, play an important role in regulating the time course, magnitude of the platform phase of action potentials and in maintaining resting potentials.

关 键 词：心肌细胞动作电位 K通道 KCN 钾通道阻断剂 不饱和脂肪酸 吸入性麻醉剂 钾离子通道 TASK 机械刺激 静息电位 

分 类 号：R33-4[医药卫生—人体生理学] R962[医药卫生—基础医学]