急性心肌梗塞患者肿瘤坏死因子和白细胞介素6水平的研究  

Levels of tumor necrosis factor α and interleukin6 in patients with acute myocardial infarction

作　　者：张炳勇[1,2,3] 张善亮[1,2,3] 伍学强[1,2,3] 张建军[1,2,3] 张文武[1,2,3] 马改风[1,2,3] 

机构地区：[1]郑州市河南省人民医院急诊科 [2]河南省胸科医院免疫研究室 [3]河南医科大学第二附属医院心内科

出　　处：《中国危重病急救医学》1996年第5期276-277,共2页Chinese Critical Care Medicine

基　　金：河南省自然科学基金资助项目

摘　　要：测定３２例急性心肌梗塞（ＡＭＩ）患者的血浆肿瘤坏死因子（ＴＮＦα）含量和白细胞介素６（ＩＬ６）生物活性。结果：ＡＭＩ患者各时间点ＩＬ６活性水平均显著高于正常对照组（Ｐ均＜０．０１），而ＴＮＦα与正常对照组相比无显著性差异（Ｐ＞０．０５）；但在ＡＭＩ发病后２４小时内心功能Ⅲ～Ⅳ级者，其最初ＴＮＦα（３．０８±１．８４μｇ／Ｌ）较心功能Ⅰ级者（１．６１±１．１５μｇ／Ｌ）显著升高（Ｐ＜０．０５）。结果提示ＴＮＦα和ＩＬ６均参与了ＡＭＩ的发病过程。作者认为可能是ＴＮＦα分泌增加而诱导免疫细胞网络系统活动性升高所致。he levels of tumor necrosis factor α (TNFα)and interleukin6(IL6)were observed in 32 patients with acute myocardial infarction(AMI).Compared with normal individuals,the levels of IL6 were increased significantly( P <0 01).There was no significant difference in plasma TNFα concentrations between the patients of AMI and normal individuals ( P >0 05).But,within 24 hours after the attack of AMI,the initial levels of TNFα were significantly higher in patients with Killip 3 or 4 than in those with Killip 1( P <0 05).These results suggest that TNFα and IL6 contribute to the development of AMI.

关 键 词：心肌梗塞 肿瘤坏死因子 白细胞介素 

分 类 号：R542.220.2[医药卫生—心血管疾病]