急性心肌梗塞患者血浆内阿片肽和精氨酸加压素含量及其临床意义  

Plasma contents of endogenous opioid peptides and arginin vasopressin in patients with acute myocardial infarction:Clinical significance

作　　者：李春盛[1] 田茹敏[1] 高秀兰[1] 李爱民[1] 齐平[1] 

机构地区：[1]北京市解放军北京军区总医院

出　　处：《中国危重病急救医学》1996年第5期287-289,共3页Chinese Critical Care Medicine

摘　　要：采用放射免疫方法测定了正常人、急性心肌梗塞和不稳定型心绞痛患者血浆β内啡肽、强啡肽和精氨酸加压素（ＡＶＰ）的浓度。结果：血浆β内啡肽、强啡肽和ＡＶＰ浓度在ＡＭＩ、不稳定型心绞痛患者较正常人明显增高（Ｐ＜０．００１，Ｐ＜０．０１），而在ＡＭＩ组与不稳定型心绞痛组３种激素浓度均无显著性差异（Ｐ均＞０．０５）。ＡＭＩ组９例有严重并发症者与１３例无并发症者相比，有并发症者３种激素均显著高于无并发症者（Ｐ均＜０．０５）。提示：缺血性疼痛是一个强的应激原，导致这些激素释放增加，另外，内阿片肽和ＡＶＰ在缺血性疼痛刺激下平行升高可能是使机体在应激状态时保持内环境的相对稳定。Radioimmunoassay was applied to determine the plasma levels of βendorphin (βEP),dynorphin(DP),arginin vasopressin (AVP) in patients with acute myocardial infarction(AMI),patients with unstable angina pectoris (AP),and normal persons.The results showed that the plasma levels of βEP,DP,AVP were significantly higher in both AMI and unstable AP groups than those in the normal control group ( P <0 001, P <0 01),while the plasma levels of the three hormones in AMI and unstalbe AP groups had no significant differences statistically ( P >0 05).In AMI group,there were 9 patients with severe complications and 13 patients without any complications.The plasma levels of the three hormones in the AMI group with complications were markedly higher than those in the AMI group without any complications( P <0 05).It is suggested that ischemic pain is a strong stressor leading to the increase of the release of the hormones.In addition,under the stimulation of ischemic pain or stress status,the parallel increases of plasma levels of endogenous opioid peptides(EOP) and AVP maintain the internal environment of the body relatively stable,which is possibly one of the adaptive compensatory mechanisms developed in the longterm evolutionary process of the body.

关 键 词：心肌梗塞 内啡肽 强啡肽 精氨酸加压素 

分 类 号：R542.22[医药卫生—心血管疾病]