皮下注射脱氧胆酸盐治疗脂肪瘤  

Lipomas treated with subcutaneous deoxycholate Injections

作　　者：Rotunda A.M. Ablon G. Kolodney M.S. 李晓莉 

机构地区：[1]Bennett Surgery Center, St. John's Medical Plaza, Santa Monica, CA 90404, United States Dr

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第3期10-11,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Lipomas are benign neoplasms of mature fat cells. Current treatments are invasive and carry the risk of scarring. Injections of phosphatidylcholine solubilized with deoxycholate, a bile salt, have been used to reduce unwanted accumulations of fat. Recent in vitro and ex vivo investigations indicate that deoxycholate alone causes adipocyte lysis. Objective: We sought to report our experience treating lipomas using subcutaneous deoxycholate injections. Methods: A total of 6 patients presenting with 12 lipomas were treated with intralesional injections of sodium deoxycholate (1.0% , 2.5% , and 5.0% ) at intervals of 2 to 20weeks. Tumor size, cutaneous reactions, and patients subjective responses were recorded before and after treatment. Results: All lipomas decreased in size (mean area reduction, 75% ; range, 37% - 100% ) as determined by clinical measurement (with ultrasound confirmation in one lipoma) after an average of 2.2 treatments. Several lipomas fragmented or became softer in addition to decreasing in volume. Adverse effects, including transient burning, erythema, and local swelling, were associated with higher deoxycholate concentrations but resolved without intervention. There was no clear association between deoxycholate concentration and efficacy. Conclusions: Our clinical experience supports our laboratory investigations demonstrating that deoxycholate, rather than phosphatidylcholine, is the active ingredient in subcutaneously injected formulas used to treat adipose tissue. This small series suggests that low concentration deoxycholate may be a relatively safe and effective treatment for small collections of fat. However, controlled clinical trials will be necessary to substantiate these observations.Background： Lipomas are benign neoplasms of mature fat cells. Current treatments are invasive and carry the risk of scarring. Injections of phosphatidylcholine solubilized with deoxycholate, a bile salt, have been used to reduce unwanted accumulations of fat. Recent in vitro and ex vivo investigations indicate that deoxycholate alone causes adipocyte lysis. Objective： We sought to report our experience treating lipomas using subcutaneous deoxycholate injections. Methods： A total of 6 patients presenting with 12 lipomas were treated with intralesional injections of sodium deoxycholate （1.0%, 2.5%, and 5.0% ） at intervals of 2 to 20weeks. Tumor size, cutaneous reactions, and patients＇ subjective responses were recorded before and after treatment. Results： All lipomas decreased in size （mean area reduction, 75%; range, 37%-100% ）as determined by clinical measurement （with ultrasound confirmation in one lipoma） after an average of 2. 2 treatments.

关 键 词：皮下注射治疗 脱氧胆酸盐 脂肪瘤 成熟脂肪细胞 瘤体大小 细胞溶解 磷脂酰胆碱 去氧胆酸钠 皮损内注射 良性肿瘤 

分 类 号：R457.2[医药卫生—治疗学] R657.420.2[医药卫生—临床医学]