UVB靶向光疗治疗斑块型银屑病  

Targeted UV-B phototherapy for plaque-type psoriasis

作　　者：Asawanonda P. Chingchai A. Torranin P. 潘敏 

机构地区：[1]Division of Dermatology,Department of Medicine,King Chulalongkorn Memorial Hospital, Rama 4 Rd,Bangkok 10330, Thailand Dr

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第3期25-25,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Objective: To determine whether targeted UV-B phototherapy is efficacious and safe in the treatment of localized psoriasis and whether there is a dose-response relationship. Design: Randomized, evaluator-blind, controlled study. Setting: Dermatology clinic in a large university-based hospital in Bangkok,Thailand. Patients: Fourteen patients with stable, localized, plaque-type psoriasis. Interventions: Patientswere randomized to receive different fluences of targeted UV-B phototherapy 3 times weekly based on predetermined minimal erythema doses(MEDs). Treatment fluences were constant throughout the study period of 4weeks. Follow-upwas carried out until lesions returned to original state. Main Outcome Measures: Modified psoriasis area and severity index. Results: All fluences of UV-B produced some clinical improvement and were very well tolerated. Fluences ranging from 1 to 6 multiples of MEDs resulted in clearance of lesions in some patients with 6 MEDs producing clearance in 77% of patients. The number of treatments required to clear psoriatic lesions when 2 to 6MEDs were used was 5.0 to 6.1 treatments. The only adverse events observed were erythema, which was asymptomatic in most subjects, and hyperpigmentation. Conclusions: Incoherent, targeted UV-B phototherapy is a safe and efficacious treatment modality for localized psoriasis. Its value in other UV-B responsive conditions should be further investigated.Objective： To determine whether targeted UV-B phototherapy is efficacious and safe in the treatment of localized psoriasis and whether there is a dose-response relationship. Design： Randomized, evaluator-blind, controlled study. Setting： Dermatology clinic in a large university-based hospital in Bangkok, Thailand. Patients： Fourteen patients with stable, localized, plaque-type psoriasis. Interventions： Patientswere randomized to receive different fluences of targeted UV-B phototherapy 3 times weekly based on predetermined minimal erythema doses（MEDs） . Treatment fluences were constant throughout the study period of 4weeks. Follow-upwas carried out until lesions re turned to original state. Main Outcome Measures： Modified psoriasis area and severity index. Results： All fluences of UV-B produced some clinical improvement and were very well tolerated. Fluences ranging from 1 to 6 multiples of MEDs resulted in clearance of lesions in some patients with 6 MEDs producing clearance in 77% of patients. The number of treatments required to clear psoriatic lesions when 2 to 6MEDs were used was 5. 0 to 6. 1 treatments. The only adverse events observed were erythema,

关 键 词：斑块型银屑病 光疗治疗 UVB 靶向 银屑病患者 银屑病皮损 最小红斑量 严重度指数 量效关系 对照研究 

分 类 号：R758.630.5[医药卫生—皮肤病学与性病学] R722.17[医药卫生—临床医学]