手背部嗜中性皮肤病与Sweet综合征的关系:9例病例报道及与非典型坏疽性脓皮病的比较  

The relationship between neutrophilic dermatosis of the dorsal hands and Sweet syndrome: Report of 9 cases and comparison to atypical pyoderma gangrenosum

作　　者：Walling H.W. Snipes C.J. Gerami P. Piette W.W. 刘艳 

机构地区：[1]Dermatology, P.C., 6000 University Ave,West Des Moines, IA 50266, United States Dr

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第3期30-31,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Neutrophilic dermatoses are a collection of diseases with varying presentation unified by clinical and histologic features. Neutrophilic dermatosis of the dorsal hands is a recently described clinical entity and an evolving disease concept. Its relationship to acute febrile neutrophilic dermatosis (Sweet syndrome), pyoderma gangrenosum, and a primary vasculitis has been debated. Observations: We present 9 cases (8 women and 1 man) of neutrophilic dermatosis of the dorsal hands, all with consistent histologic features. Two cases had histologic evidence of vasculitis, and 3 had clinical extension of lesions onto the forearms. Most showed fever, leukocytosis, and/or elevated erythrocyte sedimentation rate. Individual cases were associated with leukemia, lung carcinoma, and inflammatory bowel disease. All 9 patients responded to systemic corticosteroid therapy, with additional response to dapsone, methotrexate, and potassium iodide therapies in several cases. Of the 9 patients, 5 showed complete resolution of their skin disease, whereas 4 required ongoing therapy. We assessed the 43 cases previously reported in the literature. Conclusion: The clinical presentation, laboratory data, histologic features, and response to corticosteroid therapy offer strong evidence that neutrophilic dermatosis of the dorsal hands is a localized variant of Sweet syndrome and is also identical to atypical pyoderma gangrenosumwhen that condition presents on the hands.Background： Neutrophilic dermatoses are a collection of diseases with varying presentation unified by clinical and histologic features. Neutrophilic dermatosis of the dorsal hands is a recently described clinical entity and an evolving disease concept. Its relationship to acute febrile neutrophilic dermatosis （Sweet syndrome）, pyoderma gangrenosum, and a primary vasculitis has been debated. Observations： We present 9 cases （8 women and 1 man） of neutrophilic dermatosis of the dorsal hands, all with consistent histologic features. Two cases had histologic evidence of vasculitis, and 3 had clinical extension of lesions onto the forearms. Most showed fever, leukocytosis, and/ or elevated erythrocyte sedimentation rate. Individual cases were associated with leukemia, lung carcinoma, and inflammatory bowel disease. All 9 patients responded to systemic corticosteroid therapy, with additional response to dapsone, methotrexate, and potassium iodide therapies in several cases. Of the 9 patients, 5 showed complete resolution of their skin disease, whereas 4 required ongoing therapy.

关 键 词：SWEET综合征 嗜中性皮肤病 坏疽性脓皮病 手背部 病例报道 非典型 皮肤病患者 原发性血管炎 组织学特征 临床疾病 

分 类 号：R751[医药卫生—皮肤病学与性病学] R758.25[医药卫生—临床医学]