华法林治疗青斑样血管病变伴冷纤维蛋白血症及高同型半胱氨酸血症  

Warfarin therapy for livedoid vasculopathy associated with cryofibrinogenemia and hyperhomocysteine

作　　者：Browning C.E. Callen J.P. 刘艳 

机构地区：[1]310 East Broadway, Louisville, KY 40202, United States Dr

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第3期32-32,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Livedoid vasculopathy is an idiopathic, chronic disorder manifested by painful, purpuric macules on the lower extremities that superficially ulcerate, resulting in atrophic, stellate scars with peripheral telangiectasias and hyperpigmentation. Observations: A 50-year-old man presented with recurrent, painful ulcerations on the medial aspect of his malleoli and calves. The clinical presentation, histologic findings, and results of laboratory evaluation confirmed the diagnosis of livedoid vasculopathy in this case. Despite being refractory to treatment with multiple other medications, the lesions responded dramatically to oral warfarin sodium therapy. Conclusion: Treatment with warfarin may be a beneficial therapy for patients with livedoid vasculopathy.Background： Livedoid vasculopathy is an idiopathic, chronic disorder manifested by painful, purpuric macules on the lower extremities that superficially ulcerate, resulting in atrophic, stellate scars with peripheral telangiectasias and hyperpigmentation. Observations： A 50-year-old man presented with recurrent, painful ulcerations on the medial aspect of his malleoli and calves. The clinical presentation, histologic findings, and results of laboratory evaluation confirmed the diagnosis of livedoid vasculopathy in this case. Despite being refractory to treatment with multiple other medications, the lesions responded dramatically to oral warfarin sodium therapy. Conclusion： Treatment with warfarin may be a beneficial therapy for patients with livedoid vasculopathy.

关 键 词：青斑样血管病变 多种药物治疗 高同型半胱氨酸血症 华法林钠 蛋白血症 疼痛性溃疡 纤维 毛细血管扩张 男性患者 组织学检查 

分 类 号：R619.6[医药卫生—外科学] R735.7[医药卫生—临床医学]