中国系统性红斑狼疮患者血浆可溶性Fas水平升高与器官或组织损害相关  

Elevated levels of serum soluble Fas are associated with organ and tissue damage in systemic lupus erythematosus among Chinese

作　　者：刘艳 

机构地区：[1]不详

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第3期34-35,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：The aims of the present study are to evaluate the difference of the levels of soluble Fas (sFas) antigen between patients with systemic lupus erythematosus (SLE) and healthy controls and to explore whether sFas has a role in either the disease activity or the organ damage in SLE. Serum levels of sFas were measured in 40 Chinese patients with SLE and 15 age-, gender-, and race-matched healthy controls using double antibody ELISA. SLEDAI scores for disease activity were determined. Data of organ and tissue damage was obtained from clinical records. Serum sFas levels were significantly increased in both more active (mean = 8043.8 pg/ ml, P < 0.001) and less active SLE patients (mean = 4820.2 pg/ml, P < 0.001) comparing to the healthy controls (mean = 3253.4 pg/ml). There was also a significant difference in serum sFas levels between the more active SLE patients and less active SLE patients (P = 0.04). But, the levels of sFas didn t correlate with SLEDAI. There was a significant difference in the serum sFas levels between patients with and without CNS disease (mean = 9582.6, 6634.5 pg/ml; P = 0.007). The same was true when patients with and without renal disease (mean = 10972.7, 6520.1 pg/ml; P = 0.019), as well as serositis (mean = 10385.3, 6709.1 pg/ml; P = 0.005) were analyzed. sFas is elevated in sera of SLE patients, especially in patients with active SLE. The elevated levels of sFas in the sera of patients with SLE may be closely associated with damage to the kidneys, central nervous system and serosa. Serum sFas may serve as a predictor of some organ and tissue damage in SLE.The aims of the present study are to evaluate the difference of the levels of soluble Fas （sFas） antigen between patients with systemic lupus erythematosus （SLE） and healthy controls and to explore whether sFas has a role in either the disease activity or the organ damage in SLE. Serum levels of sFas were measured in 40 Chinese patients with SLE and 15 age-, gender-, and race-matched healthy controls using double antibody ELISA. SLEDAI scores for disease activity were determined. Data of organ and tissue damage was obtained from clinical records. Serum sFas levels were significantly increased in both more active （mean = 8043.8 pg/ml, P 〈 0. 001） and less active SLE patients （mean = 4820. 2 pg/ml, P 〈 0. 001 ） comparing to the healthy controls （mean = 3253.4 pg/ml）.

关 键 词：系统性红斑狼疮患者 血浆可溶性FAS 抗原水平 器官损害 组织损害 中国 可溶性脂肪酸合成酶 双抗体ELISA法 血浆sFas 疾病活动性 

分 类 号：R758.62[医药卫生—皮肤病学与性病学] R541.61[医药卫生—临床医学]