白癜风患者合并Sézary综合征的发病机制  

Pathogenetic mechanisms of vitiligo in a patient with Sézary syndrome

作　　者：Knol A.C. Quéreux G. Marques-Briand S. B. Dreno 冯义国 

机构地区：[1]INSERM U601, CHU Htel-Dieu, 9 quai M-oncousu, 44093 Nantes Cedex 01, France

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第3期44-45,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Patients exhibiting association between vitiligo and cutaneous T-cell lymphoma (CTCL) remain rare and it is not known whether some T-cell subpopulations of CTCL in the skin are able to recognize specific melanocytic epitopes and thus induce vitiligo. The aim of our study was to determine whether T cells specific to melanocyte differentiation antigens were detectable among tumour-infiltrating lymphocytes (TIL) in the hypopigmented skin of a patient with Sé zary syndrome (SS). A 71-year-old patient presented with SS and developed vitiligo during the course of her disease. Immunohistochemical studies showed staining with HMB45 and MelanA antibodies in the pigmented skin biopsy, whereas no staining was observed in the hypopigmented skin biopsy. To analyse responses to melanocyte differentiation antigens, we used a transient COS transfection assay that permits an estimation of CD8 T-cell responses against a- large number of HLA/antigen combinations. This technique allowed the detection of melanocyte differentiation antigen-specific T lymphocytes, directed mainly against Melan-A/MART1 antigen in the HLA-A 23 context. Our study supports the concept that vitiligo that has developed during the evolution of a CTCL is related to the presence of a T-lymphocyte subpopulation reactive against melanocyte differentiation antigens (mainly Melan-A/MART1) present in skin lesions. The role of interferon in the induction of this T-lymphocyte subpopulation is discussed.Patients exhibiting association between vitiligo and cutaneous T-cell lymphoma （CTCL） remain rare and it is not known whether some T-cell subpopulations of CTCL in the skin are able to recognize specific melanocytic epitopes and thus induce vitiligo. The aim of our study was to determine whether T cells specific to melanocyte differentiation antigens were detectable among tumour-infiltrating lymphocytes （TIL） in the hypopigmented skin of a patient with Sézary syndrome （SS） . A 71-year-old patient presented with SS and developed vitiligo during the course of her disease. Immunohistochemical studies showed staining with HMB45 and MelanA antibodies in the pigmented skin biopsy, whereas no staining was observed in the hypopigrnented skin biopsy.

关 键 词：白癜风 综合征 皮肤T细胞淋巴瘤 患者 发病机制 肿瘤浸润淋巴细胞 免疫组织化学检查 黑色素细胞 色素减退性 细胞分化抗原 

分 类 号：R758.41[医药卫生—皮肤病学与性病学] R739.5[医药卫生—临床医学]