特比萘芬引起的亚急性皮肤红斑狼疮  

Terbinafine-induced subacute cutaneous lupus erythematosus

作　　者：Farhi D. Viguier M. Cosnes A. H. Bachelez 党倩丽 

机构地区：[1]Hpital Saint-Louis,1, avenue Claude-Vellefa-ux,FR-75475 Paris Cedex 10,France Dr

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第3期53-53,共1页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Nearly 10% of lupus erythematosus (LE) are drug induced. More than 60 different drugs are involved in iatrogenic LE. We report herein 3 cases of terbinafine-ind-uced LE.Observations: Three patients receiving terbinafine for a suspected dermatophytic infection developed a subacute cutaneous LE, within 7 weeks following terbinafine introduction. The patients medical history included sicca syndrome, lung carcinoma and Kikuchi disease, respectively. Clinical remission occurred within 15 weeks following terbinafine withdrawal. Discussion: Sixteen cases of terbinafine-induced LE have been previously reported, including 13 women. The median age was 54 years. Prior autoimmunity was reported in 10 cases, including 5 pre-existing LE. The median delay between terbinafine introduction and LE onset was 5 weeks. The median time until clinical recovery following terbinafine withdrawal was 8 weeks. Conclusion: Terbinafine should be prescribed only in patients with proven dermatophytosis. We recommend cautious monitoring in patients with pre-existing autoimmunity. The diagnosis of terbinafine-induced LE should lead to the immediate and definitive withdrawal of the drug.Background： Nearly 10% of lupus erythematosus （LE） are drug induced. More than 60 different drugs are involved in iatrogenic LE. We report herein 3 cases of terbinafine-induced LE. Observations： Three patients receiving terbinafine for a suspected dermatophytic infection developed a subacute cutaneous LE, within 7 weeks following terbinafine introduction. The patients＇ medical history included sicca syndrome, lung carcinoma and Kikuchi disease, respectively. Clinical remission occurred within 15 weeks following terbinafine withdrawal. Discussion： Sixteen cases of terbinafine-induced LE have been previously reported, ineluding 13 women. The median age was 54 years. Prior autoimmunity was reported in 10 cases, including 5 pre-existing LE. The median delay between terbinafine introduction and LE onset was 5 weeks. The median time until clinical recovery following terbinafine withdrawal was 8 weeks. Conclusion： Terbinafine should be prescribed only in patients with proven dermatophytosis.

关 键 词：亚急性皮肤红斑狼疮 特比萘芬 KIKUCHI病 自身免疫性疾病 皮肤真菌感染 干燥综合征 症状缓解 中位年龄 医源性 治疗后 

分 类 号：R593.240.5[医药卫生—内科学] R978.5[医药卫生—临床医学]