中国汉族HLA-DQA1和HLA-DQB1基因与白癜风的关系  

Association of HLA-DQA1 and DQB1 genes with vitiligo in Chinese Hans

作　　者：罗素菊 

机构地区：[1]不详

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2006年第3期59-60,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：Background: Vitiligo is an acquired depigmentary disorder of the skin and hair which results from selective destruction of melanocytes. Serological typing and genotyping of human leukocyte antigen (HLA) have shown discrepancies in HLA associations with vitiligo in different ethnic populations. Methods: Polymerase chain reaction sequence-specific primer (PCR-SSP) method was used to analyze the distribution of HLA-DQA1, and -DQB1, alleles among 187 patients with vitiligo and 273 healthy controls through Epi Info version 6 package (Centers for Disease Control and Prevention, Atlanta, GA, USA). Results: The frequencies of HLA-DQA1 0302(OR = 1.98, Pc< 0.01), -DQB1 0303 (OR = 3.14, Pc< 0.001), and -DQB1 0503 (OR = 3.36, Pc < 0.05) alleles were significantly increased in patients with vitiligo compared with controls, and HLA-DQA1 0501 (OR = 0.40, Pc < 0.01) allele frequencywas highly decreased. HLA-DQA1 0302 (OR = 5.19, Pc < 0.001), -DQA1 0601 (OR= 2.95,Pc <0.05), -DQB1 0303 (OR= 4.50, Pc < 0.001), and -DQB1 0503 (OR = 6.69, Pc < 0.001) alleles were positively associated, whereas HLA-DQA1 0501 (OR = 0.05, Pc < 0.001) allele was negatively associated with childhood vitiligo patients, and HLA-DQB1 0303 (OR = 2.76, Pc < 0.001) allele was positively associated with adult vitiligo patients compared with controls. The frequency of HLA-DQB1 0303 (OR = 3.72, Pc < 0.001) allele was significantly increased in localized vitiligo patients vs. controls, whereas HLA-DQA1 0302 (OR = 2.47, Pc < 0.01), -DQB1 0303 (OR = 2.67, Pc <0.01), and -DQB1 0503 (OR = 4.46, Pc <0.01) allele frequencies were significantly increased and -DQA1 0501 (OR = 0.27, Pc <0.01) allele frequency was highly decreased in generalized vitiligo patients. Conclusions: HLA-DQA1 0302,  DQA1 0601, -DQB1 0303, and -DQB1 0503 alleles could be susceptible alleles of vitiligo, while HLA-DQA1 0501 allele could be a protective allele in Chinese Hans. There may be different genetic backgrounds between vitiligo patBackground： Vitiligo is an acquired depigmentary disorder of the skin and hair which results from selective destruction of melanocytes. Serological typing and genotyping of human leukocyte antigen （HLA） have shown discrepancies in HLA associations with vitiligo in different ethnic populations. Methods： Polymerase chain reaction sequence-specific primer （PCR-SSP） method was used to analyze the distribution of HLA-DQA1, and -DQB1, alleles among 187 patients with vitiligo and 273 healthy controis through Epi Info version 6 package （Centers for Disease Control and Prevention, Atlanta, GA, USA） . Results： The frequencies of HLA-DQA1 ＊ 0302（OR = 1.98, Pc 〈 0.01）, -DQB1＊0303 （OR = 3.14, Pc 〈 0.001）, and-DQB1＊0503 （OR = 3.36, Pc 〈0.05） alleles were significantly increased in patients with vitiligo compared with controls,

关 键 词：HLA-DQA1 HLA-DQB1基因 白癜风 中国汉族 人类白细胞抗原(HLA) HLA-DQB1等位基因 获得性色素脱失性疾病 疾病预防与控制中心 序列特异性引物 多聚酶链反应 

分 类 号：R544.1[医药卫生—心血管疾病] R457.7[医药卫生—内科学]