缓释厄贝沙坦涂层支架置入对内膜增生的影响  

Influence of slow-released erbansatan-eluting stent on neointima hyperplasia after percutaneous coronary intervention

作　　者：李光[1] 林曙光[1] 陈纪言[1] 谭虹[1] 

机构地区：[1]广东省心血管病研究所心内科,广州市510100

出　　处：《实用医学杂志》2006年第8期858-861,共4页The Journal of Practical Medicine

摘　　要：目的:探讨缓释厄贝沙坦涂层支架置入对内膜增生的影响。方法:建立冠状动脉支架置入的广西种的微型猪动物模型,分别置入普通裸支架和缓释厄贝沙坦涂层支架。于支架置入后3、7、28、90和180d截取支架段血管连同邻近的近端正常血管段,通过病理组织学分析和聚合酶链反应技术检测支架局部内膜增生情况。结果:正常血管段表达PCNAmRNA在各个时间段差异没有显著性。普通支架置入后3d局部血管壁PCNAmRNA的表达明显增高,并在术后7d达到高峰。术后90dPCNAmRNA的表达呈现下降的趋势,但仍显著高于正常血管段,并且差异一直持续到术后180d。术后第3天药物支架段PCNAmRNA的表达明显增高,并在术后7d达到高峰。术后7d药物支架段PCNAmRNA的表达已显著低于普通支架段,并且差异一直持续到术后90d。术后90～180d药物支架段内膜加中膜面积明显小于普通支架段。结论:缓释厄贝沙坦涂层支架置入可在一定程度上减少支架置入后内膜的增生反应。Objective To investigate the influence of slow-released erbansatan-eluting stent on neointima hyperplasia after percutaneous coronary intervention. Methods Established models of mini-pigs of coronary stent implantation. The process of noeintima hyperplasia and the levels of PCNA mRNA were detected at day 3, 7, 28, 90 and 180 after the procedure by histological method and reverse transcription polymerse chain reaction technique respectively. Results The levels of PCNA mRNA of the normal vessel section showed no obvious differences at every stage and sustained on a stable level. On the 3rd day after the bare stent implantation, the levels of PCNA mRNA increased significantly compared with the nearby normal vessel section and reached the peak on the 7th day. Until the 90th day after the procedure, the levels of PCNA mRNA began a declining tendency, but still obviously higher than that of the normal vessels. The differences lasted to the 180th day after the operation. On the 3rd day after the drug-eluting stent implantation, the levels of PCNA mRNA increased significantly compard with the nearby normal vessel section and reached the peak on the 7th day. On the 7th day, the levels of PCNA mRNA in drug-eluting stent group became obviously lower than that of bare stent group and the difference lasted to the 90th day. From 90th to 180th day, the areas of neointima plus media in stent sections showed much less in drug-eluting stent group than that in bare stent group. Conclusion The implantation of slow-released erbansatan-eluting stent can restrain neointima hyperplasia in some degree after percutaneous coronary intervention.

关 键 词：血管内膜 药物涂层支架 厄贝沙坦 

分 类 号：R543[医药卫生—心血管疾病]