不同蛋白质比例食物对高持续加速度暴露小鼠血液和脑组织5-羟色胺和5-羟吲哚乙酸含量的影响  

Effects of feed with different protein proportion on concentration of blood and brain 5-HT and 5-HIAA of mice exposed to high sustained +G_z

作　　者：伊长荣[1] 余红[1] 张国文[1] 杨秀芳[1] 杨昌林[1] 

机构地区：[1]空军航空医学研究所,北京100036

出　　处：《中华航空医学杂志》1996年第1期11-14,共4页

摘　　要：目的为了探索膳食与加速度耐力的关系，观察不同蛋白质比例食物对持续高加速度暴露小鼠血液和脑组织内5-羟色胺（5－HT）和5-羟吲哚乙酸（5－HIAA）含量的影响。方法体重15－20g雄性小鼠240只，随机分为A、B、C三组。A组饲料蛋白质热比为47．6％（高蛋白质组），B组为31．1％（较高蛋白质组），C组为15．0％（适量蛋白质组）。饲喂3周后各组随机取6O只暴露于＋16Gz10min，从未经＋Gz暴露和暴露后存活的各组小鼠中随机抽取12只，测定血液和脑组织内5－HT和5－HIAA含量（＋Gz暴露的小鼠于暴露后30min内采样）。结果未经＋Gz暴露的各组小鼠血液内5－HT含量无明显差异，A组小鼠血液内5－HIAA有增加的趋势；脑组织内5－HT和5－HIAA含量则随食物中蛋白质增加而增加。＋Gz暴露动物与未暴露着相比，血液中5－HT含量明显增加，而血液中5－HIAA、脑组织内5－HT及5－HIAA含量无明显差异。结论增加食物中蛋白质比例对机体加速度耐受性的影响可能与5－HT代谢有一定关系。Objective To explore the re1ationship between diet and +Gz tolerance, effects ofhigh protein feed on concentration of blood and brain 5-HT and 5HIAA of mice exposed and unexposedto high sustained Gz were studied. Methods Two hundred and forty mice were randomly devided into 3groups. To group A feed with 47. 6% protein (by calorigenic value), group B 31 % and group C 15%was given. After 3 weeks, 60 mice out of 80 were taken randomly from each group and exposed to 16 Gfor 10 min. The concentration of blood and brain 5-HT and 5-HIAA of mice exposed and unexposed to+Gz were determined. The samples of exposed mice were taken within 30 min after exposure. ResultsIn mice unexposed to +Gz,the differences of blood 5-HT concentration among 3 groups were nonsignificant, blood 5-HIAA concentration of group A was significantly higher than that of group C, whilebrain 5-HT and 5-HIAA were significantly higher in group A, B than that of group C. In mice exposedto +Gz, blood 5-HT concentration was significantly higher than that of unexposed, while brain 5-HTas well as blood and brain 5-HIAA concentration had no significant change as compared with those ofunexposed mice. Conclusions The results suggest that the effect of high protein diet on +Gz tolerancemay be related to the metabli5m of 5-HT.

关 键 词：航空医学 加速度 蛋白质 5-羟色胺 5-羟吲哚乙酸 

分 类 号：R852.21[医药卫生—航空、航天与航海医学] R854[医药卫生—临床医学]