门冬氨酸阿奇霉素与红霉素治疗支原体肺炎的临床研究  

Clinical comparative study of azithromycin aspartate and erythomycin in the treatment of mycoplasmal pneumoniae

作　　者：杨勇[1] 陈自励[1] 黄立文[1] 邹明艳[1] 徐强（编校） 

机构地区：[1]广东省东莞市妇幼保健院儿科,523002 [2]不详

出　　处：《中国妇幼保健》2006年第8期1086-1087,共2页Maternal and Child Health Care of China

摘　　要：目的:比较门冬氨酸阿奇霉素与红霉素治疗儿童支原体肺炎的临床疗效和不良反应。方法:将54例支原体肺炎患儿随机分为两组,34例采用门冬氨酸阿奇霉素10 mg.kg-1.d-1静脉滴注,用药3 d停4 d(>5岁者停3 d),再用3 d;20例静脉滴注红霉素30 mg.kg-1.d-1,疗程10 d。治疗结束后根据疗效评定标准比较两组疗效和不良反应。结果:门冬氨酸阿奇霉素和红霉素治疗儿童支原体肺炎均有较好的疗效,但门冬氨酸阿奇霉素组临床症状恢复时间、临床痊愈率均优于红霉素(P<0.05),而不良反应发生率低于红霉素(P<0.05)。结论:静脉滴注门冬氨酸阿奇霉素治疗儿童支原体肺炎疗效确切,治疗时间短,不良反应少,患儿依从性好,值得在临床上推广使用。Objective： To compare the efficacy and adverse reactionsof azithromycin aspartate and erythromycin for the treatment of mycoplasmal pneumonia in children. Methods： 54 children withmycoplasmal pneumoniae were selected and randomly divided intotwo groups. 34 children were treated with injectable azithromycin aspartateat a dose of 10 mg/kg once daily for 3 days, followed by the same treatmentafter 4 days （if 〉5 years of age after 3 days） . 20 children were treatedwith injectable erythromycin at a dose of 30 mg/kg once daily for 10 days. The efficacy were assessed by evaluating standard of therapeutic effectand the adverse reactions were compared after treatment. Results： Therewere good therapeutic effect in either treatment group. Bt the recoverytime of clinical symptoms was faster, the clinical cure rate was higherand the adverse reactions was lower in azithromycin aspartate group than those in erythromycin group. Conclusion： Azithromycin aspartate appears to have better effective and fewer side effects than erythromycin for the treatment of mycoplasmal pneumonia in children.. It should be promoted widely for clinical use.

关 键 词：门冬氨酸阿奇霉素 支原体 肺炎 临床疗效 

分 类 号：R725.6[医药卫生—儿科]