北京市乙型肝炎疫苗母婴阻断效果监测分析  

Analysis on the Efficacy of Hepatitis B Vaccine in the Supervised Children Born to HBsAg Carrier Mothers in Beijing

作　　者：王富珍[1] 龚晓红[2] 李辉[3] 刘立荣[2] 张海艳[4] 汪侠[5] 韩庆英[6] 张震[7] 韩莉莉[2] 

机构地区：[1]北京护士学校,北京101149 [2]北京市疾病预防控制中心,北京100013 [3]中国医学科学院基础医学研究所,北京100005 [4]北京市东城区疾病预防控制中心,北京100009 [5]北京市海淀区疾病预防控制中心,北京100080 [6]北京市大兴区疾病预防控制中心,北京102600 [7]北京市西城区疾病预防控制中心,北京100029

出　　处：《中国计划免疫》2006年第2期97-99,共3页Chinese Journal of Vaccines and Immunization

基　　金：北京市科学技术委员会基金资助项目(H010910230119)

摘　　要：目的评价北京市现行乙型肝炎（乙肝）疫苗（HepB）免疫策略的母婴阻断效果。方法利用北京市1999～2004年部分区对母亲乙肝病毒表面抗原（HBsAg）阳性的儿童进行HepB免疫后的血清学监测资料，对母亲HBsAg阳性儿童的血清HBsAg、乙肝病毒表面抗体（抗-HBs）和乙肝病毒核心杭体（抗-HBc）水平以及疫苗保护水平进行分析。结果所监测的727名儿童中，HBsAg阳性率为2．5％。母亲[HBsAg、乙肝病毒膜抗原（HBeAg）]双阳性者HBsAg阳性率高于母亲单阳性者。抗-HBc阳性率为6．1％，母亲单阳性者和母亲双阳性者差异无显著的统计学意义。抗-HBs阳性率为85．7％，抗体几何平均浓度（GMC）为90．4毫国际单位／毫升（mIU／ml），且母亲单阳性者抗-HBs阳性率高于母亲双阳性者。HepB保护率为92．2％（95％CI：90．3％～94．1％），其中对母亲单阳性者的保护率为93．4％（95％CI：92．3％～94．5％），对母亲双阳性者的保护率为89．3％（95％CI：87．2％～91．4％）。结论北京市现行HepB免疫策略对母亲HBsAg阳性儿童的免疫保护效果理想。Objective To evaluate the efficacy of Hepatitis B vaccine in the children born to HBsAg carrier mothers under the Hepatitis B vaccine immunity strategy of Beijing. Methods The supervising blood serum data of the children born to HBsAg carrier mothers in the years from 1999 to 2004 were collected. The positive rate of HBsAg, anti-HBs,anti-HBc and the protective rate were analyzed. Results A total of 727 children born to HBsAg carrier mothers were vaccinated according to the Hepatitis B vaccine immunity strategy of Beijing. The positive rate of HBsAg and anti-HBs were 2.5 % and 85.7 % respectively. The positive rate of HBsAg among the children born to HBsAg and HBeAg carrier mothers was higher than the rate among the children born to HBsAg carrier mothers. The GMC of anti-HBs was 90.4 mIU per mL. The protective rate of Hepatitis B was 92.2 % （95 % CI ： 90.3 % - 94.1% ）. The protective rate among the children born to HBsAg carrier mothers was 93.4 % （95 % CI：92.3 % -94.5 % ） and among the children born to HBsAg and HBeAg carrier mothers was 89.3%（95% CI：87.2% -91.4%） . Conclusions The Hepatitis B vaccine immunity strategy of Beijing had good immunological and protective efficacy to HBV interruption of perinatal transmission.

关 键 词：乙型肝炎疫苗 母婴阻断 效果 

分 类 号：R186[医药卫生—流行病学] R512.6[医药卫生—公共卫生与预防医学]