甘肃省2001～2003年检出脊髓灰质炎疫苗株病毒的急性弛缓性麻痹病例流行病学分析  

Epidemiologic Analysis on AFP Cases From Whom Polio Vaccine Virus Was Isolated in Gansu Province During 2001-2003

作　　者：李凤琴[1] 李慧[1] 屠爱霞[1] 

机构地区：[1]甘肃省疾病预防控制中心,兰州730000

出　　处：《中国计划免疫》2006年第2期134-136,共3页Chinese Journal of Vaccines and Immunization

摘　　要：目的研究脊髓灰质炎（脊灰）疫苗株病毒阳性病例的流行病学特征。方法对甘肃省2001～2003年相关资料进行描述流行病学分析。结果从331例急性弛缓性麻痹（AFP）病例的316例粪便标本中，检出脊灰病毒16例，检出率5．06％，均为脊灰疫苗相关株病毒。病例散在发生，无聚集性。所有病例年龄≤5岁。临床表现以发热、腹泻、肢体感觉障碍、深部腱反射减弱或消失为主。麻痹部位以单下肢和双下肢为主，分离出Ⅱ型脊灰病毒的病例残留麻痹最多。疫苗相关麻痹型脊灰（VAPP）的发生率0．87／100万，其中首次服苗后为0．98／100万，接触服苗者为0．50／100万。结论无脊灰维持阶段，VAPP、疫苗重组脊灰病毒（VRPV）和疫苗衍生脊灰病毒（VDPV）导致的病例不容忽视．保持高质量的监测和高水平接种率均是重要的。Objective In order to find out epidemic regulation of AFP cases. Methods Poliovirus and relevant data in Gansu Province in 2001-2003 were analyzed. Results 16 of 331 AFP cases＇ stool were isolated poliovirus, isolated rate is 5.06 96, all of which were vaccine associated poliovirus. All cases were sporadic and under 5 years old children, most of them were under 2 years old. The main clinic signs were fever, diarrhea, sensorial disorder of extremity, weakened or disappeared deep tendinous reflect. The main paralysis position was single or both crura, and paralysis residue of type Ⅱ was prevalent. The incidence rate of VAPP is 0.87/1000000, among which incidence rate of VAPP after first dose is 0.98/1000000, contact 0.50/1000000. Conclusion We can conclude that VAPP, VRPV, and VDPV cases can not be ignored in course of polio-free. It is important to keep high-level surveillance and vaccination coverage.

关 键 词：急性弛缓性麻痹 脊髓灰质炎疫苗株病毒 流行病学分析 

分 类 号：R512.4[医药卫生—内科学]