通心络对颈动脉粥样硬化炎性机制作用的临床研究  

Clinical evaluation of effect of Tongxinluo on inflammatory mechanism of carotid atherosclerosis

作　　者：李晋芳[1] 胡长林[1] 谢运兰[1] 童林艳[1] 

机构地区：[1]重庆医科大学附属第二医院神经内科,400010

出　　处：《重庆医学》2006年第8期712-713,共2页Chongqing medicine

摘　　要：目的探讨通心络对动脉粥样硬化炎性机制的作用,并观察其对颈动脉粥样硬化斑的影响。方法经体外血管超声检查有颈动脉粥样硬化斑块患者100例,均在降纤、抗凝、脑细胞活化剂等常规治疗基础上加服通心络胶囊(每次4粒,每日3次)3个月,每位患者均检测治疗前后血清CRPs、ICAM-1、P-选择素、MCP-1、MMP-9、血脂等的变化,同时经颈动脉彩超观察其硬化斑的变化。结果经过3个月的治疗后,患者血清CRP、sICAM-1、P-选择素、MCP-1、MMP-9水平较治疗前显著降低(P<0.05);而治疗前后血脂水平差异无统计学意义(P>0.05);颈动脉彩超观察显示,治疗后动脉硬化斑块较治疗前有不同程度减轻。结论颈动脉粥样硬化患者在常规治疗基础上加用通心络胶囊能明显降低血清炎症因子的浓度,从而减轻对血管内皮的炎症损害作用,进一步恢复内皮功能,减少动脉粥样硬化的发生发展,并能稳定斑块,提高临床疗效。Objective To evaluate the effect of Tongxinluo on the inflammatory mechanism of atherosclerosis, and to observe the effect on the atherosclerotic plaques. Methods One hundred patients with atherosclerotic plaque in carotid confirmed with ultrasonography were treated with defibrination, anticoagulation, brain cell activator and oral Tongxinluo capsule（4 pieces, t. i. d ）for 3 months. To examine the serum level of CRP, sICAM-1, MCP-1 ,P-selectin, MMP-9 ,lipid and to observe the change of atherosclerotic plaques with ultrasonography before and after 3-month treatment. Results After 3-month treatment the serum CRP,sICAM-1, MCP-1,P-selection and MMP-9 were significantly decreased than before （P〈0.05）, but the serum level of lipid did not significantly change（P〈0.05）. The atherosclerotic plaque was alleviated more or less. Conclusion Tongxinluo with conventional treatments can improve clinical curative effect in patients with carotid atherosclerosis through decreasing serum cytokines concentratin, alleviating the injure of inflammatin and renewing the function of endothelium, make the atherosclerotic plaques more stable and then decrease the development of atherosclerosis.

关 键 词：动脉粥样硬化 炎症因子 血脂 通心络胶囊 

分 类 号：R277.7[医药卫生—中医学]