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作 者:朱文昱[1] 谭丽萍[1] 陈香凤[1] 黄强[1] 兰青[1]
出 处:《中华医院感染学杂志》2006年第4期385-388,共4页Chinese Journal of Nosocomiology
摘 要:目的分析神经外科重症监护室肺部真菌感染的高危因素,探讨早期诊治的对策。方法按目前国内对肺部真菌感染的诊断标准,分析收治我科重症监护室的58例肺部真菌感染患者的临床资料。结果58例患者共分离出真菌117株,其中念珠菌属占92.3%;高危因素包括基础疾病重、昏迷时间长,长期应用广谱抗生素、大剂量使用激素、气道开放和各类有创导管等;氟康唑治疗效果好。结论重视消除肺部真菌感染的高危因素,早期诊断和早期预防性使用抗真菌药物能有效降低肺部真菌感染的发生率。OBJECTIVE By analyzing the high risk factors for pulmonary fungus infection in intensive care units of neurosurgery, this paper may be regarded as a good reference for early diagnosis and treatment. METHODS According to the domestic diagnostic standard on pulmonary fungus infection, we analyzed the clinical data of 58 patients with pulmonary fungus infection in department of neursurgery. RESULTS Totally 117 strains of fungi were isolated from the 58 cases. Candidiasis was the most frequent type, accounting for 92.3%. Some factors, such as the severity of underlying diseases, long-time coma, long-term use of broad-spectrum antibiotic, abuse of glucocorticoid, the open airway and some traumatic intubations might be regarded as the high risk factors for pulmonary fungus infection. Fluconazole showed good clinical effects on the treatment of fungus infection. CONCLUSIONS It is important to eliminate the high risk factors for pulmonary fungus infection, to provide early diagnosis and to use prophylactic antifungal agent, which can reduce the incidence rate of pulmonary fungus infection.
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