磷酸镁骨黏合剂生物学固定强度及组织学的实验研究  

Experimental study on biological fixation intensity and histology of magnesium phosphate cement

作　　者：吴建国[1] 俞永林[1] 刘昌胜[2] 丁光宏[3] 郭瀚[2] 李信安[3] 周仲文[4] 朱虹光[4] 黄煌渊[1] 

机构地区：[1]复旦大学附属华山医院骨科,上海200040 [2]华东理工大学生物材料研究所 [3]复旦大学力学系 [4]复旦大学附属华山医院外科病理室,上海200040

出　　处：《上海医学》2006年第4期230-232,共3页Shanghai Medical Journal

基　　金：上海市科学技术委员会基金资助项目(034119904)

摘　　要：目的研究磷酸镁骨黏合剂(MPC)植入家兔骨内的生物学固定强度,并作组织学观察。方法①生物力学部分:双侧股骨髁上钻孔后,分别植入MPC和磷酸钙骨水泥(CPC),术后分别饲养1、2、3、4、6和8 周后取出股骨下段作推出试验。②组织学部分:家兔右股骨髁上钻孔后填入MPC,术后分别饲养24 h、1、2周和 1、2、3个月,分批处死后取出标本,作不脱钙病理切片。结果①生物力学部分:在不同时间,MPC组的生物学固定强度均显著大于CPC组(P<0．05)。②组织学部分:2周时MPC开始吸收,2个月时MPC已完全吸收,骨孔愈合良好。结论 MPC的生物学固定强度比CPC大,且MPC可降解,可用于骨折黏合固定。Objective To investigate the effects of magnesium phosphate cement （MPC） on biological fixation intensity and histological change in rabbits. Methods ① Biomechanics： the MPC or calcium phosphate cement （CPC） was implanted into the intercondylar region of bilateral femurs in 36 rabbits, then the push-out tests were made at 1, 2, 3, 4, 6, 8 weeks after the procedure. ② Histology： MPC was implanted into the condylar region of the right femur in 32 rabbits. The non-decalci fication patholigic examinations were undertaken at 24 hours, 1, 2 weeks, 1, 2, 3 months after the procedure. Results ①Biomechanics：The average biological fixation intensities of MPC were stronger than those of CPC in any different periods, with significant statistical difference（P 〈 0.05）.②Histology： MPC began to be absorbed by the tissues after 2 weeks of implantation, and was completely absorbed with in two months. The bone fenestra in the condylar region of femur was healed. Conclusions The biological fixation intensity of MPC is stronger than that of CPC. MPC can be absorbed gradually and might potentially be used for fracture adhesive treatment. （Shanghai Med J, 2006, 29：230-232）

关 键 词：磷酸镁骨黏合剂 生物力学 组织学 磷酸钙骨水泥 

分 类 号：R318.08[医药卫生—生物医学工程] R988.2[医药卫生—基础医学]