内蒙古地区柯萨奇B组病毒及分型与病毒性心肌炎的相关性研究  

The Study of Coxsackie B Virus and Its Relationship with Viral Myocarditis in the Area of Inner Mongolia

作　　者：朱华[1] 韩晓芳[1] 王文兰[1] 于少飞[1] 李慧君[1] 

机构地区：[1]内蒙古自治区医院儿科检验科,内蒙古呼和浩特010017

出　　处：《内蒙古医学杂志》2006年第4期315-316,共2页Inner Mongolia Medical Journal

基　　金：内蒙古科技厅2003年攻关课题(20030607)

摘　　要：目的:了解内蒙古地区病毒性心肌炎(VMC)的柯萨奇B组病毒(CBV)感染特点。方法:采用酶联免疫吸附实验(ELISA),定量检测CBVB1-6IgM抗体。结果:CBVB1—6型IgM抗体阳性检出率52.5%(72/137),B3型最高占40.3%(29/72),其次依次为B2型、B4型、B5型,分别为26.4%(19/72)、20.8%(15/72)、6.9%(5/72),B1型和B6型各2.8%(2/72):而对照组IgM抗体阳性检出率为13.6%(19/140)。病毒性心肌炎血清中CBV1-6型IgM抗体阳性检出率明显高于对照组,两者差异有显著性。结论:内蒙古地区柯萨奇B组病毒感染是病毒性心肌炎的主要病因。Objective：To find out characteristic of Coxsackie B virus（CBV） from Viral myocarditis in the area of Inner Mongolia. Methods：The ELISA test was used. Results： The total positive rate of CBV 1 -6IgM antibodies was 52.5 % （72/137）, CBVB3 type was as high as 40.3 % （29/72）, the others were B2,B4,B5 BI,B6 of 26.4 % （ 19/72）, 20.8 % （ 15/72）, 6.9 % （ 5/72）, 2.8 % （2/72）, 2.8 % （2/72） respectively. Meanwhile only 13.6% （19/140）CBV IgM positive cases could be detected in the control group. The result showed that the positive rate of CBV 1 - 6 IgM antibodies in clinically diagnosed myocarditis was significantly higher than in the control group. Conclusions ：The CBV may be the main agents causing VMC in the area of Inner Mongolia.

关 键 词：柯萨奇B组病毒 IGM抗体 病毒性心肌炎 

分 类 号：R542.2[医药卫生—心血管疾病]