硅凝胶体系中不同结构羧酸钾对草酸钙结晶的影响  

Effect of Different Kinds of Potassium Carboxylates on Growth of Calcium Oxalate Crystals in Silica Gel System

作　　者：柳一鸣[1] 袁欢欣[2] 陈村元[2] 姚秀琼[2] 谭燕华[2] 欧阳健明[2] 

机构地区：[1]湖南理工大学化学化工系,湖南岳阳414000 [2]暨南大学生物矿化与结石病防治研究所,广州510632

出　　处：《化学学报》2006年第8期779-783,共5页Acta Chimica Sinica

基　　金：国家自然科学基金(No.20471024);广东省"千百十工程"优秀人才培养基金(No.Q02060)资助项目.

摘　　要：采用扫描电子显微镜(SEM)和X射线衍射(XRD)方法研究了硅凝胶体系中不同种类羧酸钾对草酸钙(CaC2O4)晶体生长的调控作用.加入一元醋酸钾(KOAc)只生成一水草酸钙(COM)晶体;三元柠檬酸钾(K3Cit)和四元乙二胺四乙酸二钾(K2EDTA)可诱导二水草酸钙(COD)形成,且随着其浓度增加,对COD的诱导能力增加,而二元酒石酸钾(K2Tart)同时诱导了COM,COD和三水草酸钙(COT)生成.随着结晶温度降低,多元酸钾可以进一步减小COM晶体的比表面积,增加COD的百分含量,但K2Tart诱导COT的能力减弱.由于诱导COD和COT晶体形成、减小COM的比表面积均有利于防止草酸钙尿石的形成,因此,多元羧酸钾可用于草酸钙结石的预防和治疗.The effect of different kinds of potassium carboxylates on the crystallization of calcium oxalate （CAC204） was investigated in silica gel system by means of scanning electron microscopy and X-ray diffraction. The investigated potassium carboxylates included： monocarboxylate potassium acetate （KOAc）, dicarboxylate potassium tartrate （K2Tart）, tricarboxylate potassium citrate （K3Cit）, and tetracarboxylate dipotassium of ethylenediaminetetraacetic acid （K2EDTA）. KOAc can only induce calcium oxalate monohydrate （COM）, while K3Cit and K2EDTA induce COM and calcium oxalate dihydrate （COD）. The ability of multicarboxylates to induce COD formation was increased with increasing their concentrations. Calcium oxalate trihydrate （COT） was induced by K2Tart. As the crystallization temperature was decreased, the percentage of COD crystals increased, the surface area of COM crystals decreased, but the percentage of COT crystals induced by K2Tart decreased. Since both increasing the content of COD or COT and decreasing the surface area of COM crystals favor the inhibition of CAC204 stones, potassium multicarboxylates can be used to prevent and cure this disease.

关 键 词：草酸钙 羧酸钾 尿结石 

分 类 号：R691.4[医药卫生—泌尿科学]