参蛇偏瘫胶囊对局灶脑缺血大鼠降钙素基因相关肽和内皮素含量的影响  

Effects of Shenshe Piantan Capsule on Calcitonin Gene-related Peptide and Content of Endothelin in Local Cerebral Ischemic Rats

作　　者：周刚[1] 韩群英 赵敏[3] 韩彩红 王忠[4] 荆志伟[4] 

机构地区：[1]北京中医药大学,北京100029 [2]河南省中医中风病工程技术研究中心,河南郑州450008 [3]天津中医学院,天津300193 [4]中国中医科学院西苑医院,北京100091

出　　处：《中国中医基础医学杂志》2006年第3期164-166,共3页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：2004年河南省科技厅科技攻关项目(0324410001)

摘　　要：目的:观察参蛇偏瘫胶囊对大鼠局灶脑缺血模型神经肽的影响,探讨其治疗脑缺血的可能机制。方法:采用FeCl3致大脑中动脉栓塞模型,应用放免法测定SD和自发性高血压大鼠(HSR)血浆、下丘脑中ET和CGRP含量。结果:参蛇偏瘫胶囊可明显拮抗缺血24h以内的血浆CGRP降低及ET的升高,提高SHR脑缺血时脑组织CGRP含量。结论:参蛇偏瘫胶囊主要对缺血早期CGRP和ET的异常变化有改善作用,而对缺血后期神经肽尚无明显影响,且以升高血浆及下丘脑中CGRP含量为主,对血浆ET的升高也有一定影响。Objective：To in vestigate the effect of Shenshe Piantan Capusle （SPC） on neuropeptide in focal stroke rats and elucidate the mechanisms. Methods： The content of endothelin （ET） and calcitonin gene related peptide（CGRP） in plasma and hypothalamus was measured via radioimmunoassay in both SD rats and spontaneous hypertension rats（SHR） with middle cerebral artery infarction. Results： Oral treatment with SPC counteracted both the decrease of CGRP and rise of NT in plasma during 24 hours after in farction and increased CGRP level in ischemic region in SHR. Conclusion ： SPC increases CGRP level in both plasma and hypothalamus, and in hibits the increase of plasma NT in the early phase of stroke, no action on neuropeptide in the late phase of stroke was observed.

关 键 词：中风 参蛇偏瘫胶囊 降钙素基因相关肽 内皮素 

分 类 号：R285.5[医药卫生—中药学]