锰神经毒性机制的研究进展  

Mechanism of Manganese Neurotoxicity

作　　者：杜凤其[1] 姜岳明[2] 莫雪安[1] 胡万达[2] 

机构地区：[1]广西医科大学第一附属医院神经内科,广西南宁530021 [2]广西医科大学劳动卫生与毒理学教研室,广西南宁530021

出　　处：《铁道劳动安全卫生与环保》2006年第2期109-112,共4页Railway Occupational Safety Health & Environmental Protection

摘　　要：锰主要以烟尘形式经呼吸道吸收,而有机锰可经皮肤吸收,也可直接通过鼻腔经嗅丝转运到达中枢神经系统。锰毒作用主要表现在神经系统,早期以神经衰弱综合征为主,晚期则以锥体外系神经障碍为主,但其神经毒性机制尚未完全清楚。本文仅从锰引起神经递质代谢紊乱、突触传导功能障碍、自由基损伤、细胞凋亡、基因多态性等方面的研究进展作一综述。Mn mainly enters the body by inhalation, but organic Mn enters the body by skin absorbing, and growing evidence suggests that nasal deposition and transport along olfactory neurons represents another route by which inhaled Mn is delivered to certain regions of brain. Mn neurotoxicity mainly shows manifestations in nerve system. The early manifestations mainly are neurasthenic syndrome, and it shows extracorticospinal tract disorders in advanced stage. Mechanism of Mn neurotoxicity is not elucidate clearly. Academicians have been studying on disorders of neurotransmitter, dysfunction synaptic conduction, injury of free radical, apoptosis and gene polymorphism.

关 键 词：锰 神经毒性 机制 皮肤 

分 类 号：R135.1[医药卫生—劳动卫生]