甲基苯丙胺及安啡拉酮的精神依赖性评价  

ASSESSMENT OF METHAMPHETAMINE AND AMFEPRAMONEPSYCHOLOGICAL DEPENDENCE POTENTIAL BYINTRAVENOUS SELF -ADMINISTRATION IN RATS

作　　者：章敏[1] 谢潞[1] 郑继旺[1] 

机构地区：[1]北京医科大学中国药物依赖性研究所

出　　处：《中国药物依赖性通报》1996年第1期19-24,共6页

摘　　要：本文采用大鼠静脉自身给药实验法评价甲基苯丙胺及其衍生物安啡拉酮的精神依赖性潜力。在自身给药形成实验中，当甲基苯丙胺剂量分别０．２５、０．１２５、０．０６２５ｍｇ·ｋｇ－１（注射）时，大鼠在固定比率程序控制下，可以对甲基苯丙胺形成稳定的自身给药反应，有剂量效应关系；当安啡拉酮日剂量相当于人剂量的２．０、５．０、７．０倍时，大鼠对安啡拉团仅产生比盐水稍高的反应率，不稳定，且无剂量效应关系。在替代实验中，大鼠先形成稳定的甲基苯丙胺自身给药行为，安啡拉酮（日剂量相当于人剂量的２－５倍）可以替代甲基苯丙胺维持自身给药反应，有剂量效应关系，但反应率不稳定。在累进比率程序控制下，甲基苯丙胶的自身给药反应“终止点”随剂量的增加而增大。实验表明甲基苯丙胺有较强的精神依赖性潜力，而安啡拉酮较弱。The psychological dependence potential of methamphetamine and amfepramone was evaluated by intravenous self -- administration in rats. Under fixed -- ratio1 schedule, increasing the dose of methamphetamine from 0. 0625 to 0. 25 mg .kg-1/injresulted in an inversely related decrease in the number of drug injections. On the contrary, under a progressive -- ratio schedule, the breaking -- point was found to vary directly as a funcion of drug dose was within the same range of doses of methamphetamine. In addition. We found under fixed -- ratio schedule amfepramone, as a substitute of methamphetamine, could also make rats maintain lever-- press responding,although it couldn' t make rats establish drug -- seeking behavior directly. The conclusions of the research are as follows: (1) the reinforcing efficacy of methamphetamine ismuch stronger than that of amfepramone; (2) the self -- administration behavoir of rats,reinforced under a progessive ratio schedule can provide useful information aboutchanges in the reinforcing efficacy of specific drugs.

关 键 词：甲基苯丙胺 安啡拉酮 精神依赖性 药物依赖 

分 类 号：R595.3[医药卫生—内科学]